RX314 Module 8

Functional genomics

Focuses on genome-wide patterns of gene expression, the mechanisms by which gene expression is coordinated, and the interpretations of gene expression when a cellular environment change occurs

DNA microarray

Chip prepared by attaching 25,000 or more oligos, which each oligo corresponding to a specific gene

Proteomics

Area of modern science dealing with cells' protein continuum aiming to identify a specific protein and correlate it with a function

Transcriptomics

Deals with RNA sequences in the genome

HER2

Growth factor overexpressed in 25-30% of human breast cancers

Transtuzumap (herceptin)

Breast cancer medication only prescribed unless the patient has first tested positive for HER2 over-expression

Only one statement about proteomics is incorrect. Which one is it?

Because each human cell has the same set of genes, proteomes for different cells are also the same.

3 multiple choice options

Only one statement about DNA microarrays is incorrect. Which one is it?

Gene expression profile for a specific type of cancer is the same for different patients.

3 multiple choice options

Only one statement about data analytics and bioinformatics is incorrect. Which one is it?

HER2 gene mutation is responsible for all breast cancer cases.

3 multiple choice options

Only one statement about omics is correct. Which one is it?

The total DNA isolated from a human cell represents the human genome.

3 multiple choice options

Only one statement about NGS transcriptomics is incorrect. Which one is it?

Considering we have 25,000 genes, using NGS we need one sequencing read per gene (25,000 total reads) to see the gene expression profile of the cell.

3 multiple choice options