Statins and non-statin cholesterol drugs

What interaction is important to remember for fibrate-class cholesterol lowering drugs?

-Fibrates + Statins shouldn’t be taken together due to high risk of myopathy and liver damage

The side effects of taking Lovasa (fish oil) for high cholesterol are _________, _______, ________

-Fishy aftertaste

-GI upset

-Risk of bleeding

The indication for non-statin cholesterol drugs is to __________

-Reduce cholesterol levels

Statins are indicated to _________

-Reduce risk of cardiovascular events

The side effects of statins include ______, _______, and ________

-GI upset

-Myalgia

-Rhabdomyolysis

Interactions with statins include _______, ________, ________

-CI in pregnancy

-Grapefruit inhibits metabolism

-Fibrate use increases myopathy risk

Atorvastatin

Lipitor

Statin

Lovastatin

Mevacor

Statin

Simvastatin

Zocor

Statin

Rosuvastatin

Crestor

Statin

Pravastatin

Pravachol

Statin

Ezetimibe/Simvastatin

Vytorin

Statin + Cholesterol absorption inhibitor

Ezetimibe

Zetia

cholesterol absorption inhibitor

Niacin

Niaspan, Vitamin B3

non-statin cholesterol reducer

Fenofibrate

Tricor

Fibrate cholesterol reducer

Gemfibrozil

Lopid

Fibrate cholesterol reducer

Fish oil

Lovaza

Non-statin cholesterol reducer

Alirocumab

Praluent

PCSK9 inhibitor, cholesterol reducer

Evolocumab

Repatha

PCSK9 inhibitor, cholesterol reducer