Cells & Tissues of the Adaptive Immune System (7)

What is a unique characteristic of T and B cells?

Expression of antigen-specific receptors

Antigen-specific receptors of B cells?

B-cell receptor (BCR), which is a membrane-bound Ig

Antigen specific receptors of T cells?

T-cell receptor (TCR)

What serves as markers for each specific cell type?

Additional cell surface

What does CD stand for?

Cluster of differentiation

origin of T and B cells creation?

Common lymphoid precursor

Where does initial maturation of T and B cells occur?

Primary lymphoid tissues/organs

What are the primary lymphoid organs?

Thymus, bone marrow, bursa of Fabricius (birds), and ileal Peyer's patches (ruminants)

Where do T cells develop?

Thymus

Where do B cells develop?

Bone marrow, bursa of Fabricius, or ileal Peyer's patches

What does maturation of T and B cells in primary lymphoid organs lead to?

Expression of unique antigen-specific receptor by each T and B cell

Expression of unique antigen-specific receptor by each T and B cell

Generation of diversity

What happens after T and B cells mature?

They enter the blood and recirculate between blood, secondary lymphoid tissues/organs, and lymph

What are the secondary lymphoid tissues and organs?

Lymph nodes, spleen, and mucosa-associated lymphoid tissue (MALT)

Encapsulated secondary lymphoid tissues/organs

Lymph node and spleen

Unencapsulated secondary lymphoid tissues/organs

Mucosa-associated lymphoid tissue (MALT)

Where do T and B cells meet their specific antigens and immune responses occur?

Secondary lymphoid tissues/organs

T and B cells meet their specific antigens and immune responses occur

Clonal selection and expansion

Antigens delivered from tissues are found where?

Lymph nodes

Antigens delivered from blood are found where?

Spleen

Antigens delivered at mucosal sites are found where?

MALT

Site of lymphocyte development from stem cell precursor

Primary lymphoid tissue/organs

What occurs in the primary lymphoid tissue/organs?

Generation of diverse T and B cell receptors

Site of initiation of the adaptive immune response

Secondary lymphoid tissue/organs

What occurs in secondary lymphoid tissue/organs?

Clonal selection and clonal expansion of antigen-specific T and B cells