Immuno (Lineage 1. Terminal / Late Signal)

0.0(0)
Studied by 0 people
call kaiCall Kai
Locked
learnLearn
examPractice Test
spaced repetitionSpaced Repetition
heart puzzleMatch
flashcardsFlashcards
GameKnowt Play
Card Sorting

1/5

encourage image

There's no tags or description

Looks like no tags are added yet.

Last updated 3:29 AM on 9/8/26
Name
Mastery
Learn
Test
Matching
Spaced
Call with Kai
Chat

No analytics yet

Send a link to your students to track their progress

6 Terms

1
New cards

Neutrophils

G-CSF →STAT3 →C/EBP epsilon


Cytokine → TF → Secondary TF

2
New cards

Eosinophils

IL-5 →GATA-1 + C/EBP alpha


Cytokine → TFs

3
New cards

Monocytes/Macrophages

M-CSF →CSF-1R →High PU.1 + Egr1


Cytokine → M-CSF Receptor → TFs

4
New cards

Conventional Dendritic Cells

Flt3-L →STAT3 →IRF8 / BATF3


Cytokine/GF → TF → Terminal TFs

5
New cards

Plasmacytoid Dendritic Cells

Flt3-L + high steady E2A expression


Cytokine/GF → TF

6
New cards

Match each hematopoietic growth factor to its receptor and primary cellular target, using the table from Lecture 3: SCF, G-CSF, M-CSF

SCF → c-Kit → HSC/MPP (survival, proliferation, self-renewal).

TPO → c-Mpl → HSC/MEP (LT-HSC quiescence,

megakaryocyte/platelet production).

EPO → EPOR → CFU-E/Pro-E (prevents apoptosis of erythroid progenitors).

G-CSF → G-CSFR → GMP/neutrophil (drives neutrophil production, HSC mobilization).

M-CSF → CSF1R →

MDP/monocyte (monocyte/macrophage differentiation).

IL-7 → IL-7Rα (CD127) → CLP/B & T (lymphopoiesis).