Antibiotics 1 - cell wall inhibitors

List the Penicillinase Resistance PCNS (AKA anti-staph)

Nafcilllin (IV), Oxacillin (IV), Dicloxacillin (PO)

List the amino penicillins

→Ampicillin

→Amoxicillin

List the PCN/B lactamase inhibitors

→Piperacillin/tazobactam

→amox/clav

→Ampi/sulbactam

Which penicillins cover strep?

all

Which penicillins cover MSSA?

List the Penicillinase Resistance PCNS (AKA anti-staph)
PCN/B lactamase inhibitors

Which penicillin covers coagulase negative staph? (CoNS)

List the Penicillinase Resistance PCNS (AKA anti-staph)

Which penicillins cover MRSA

None

Which penicillins cover VSE (vanco-susceptible enterococci)

Aminopen
PCN/B lactamase inhibitors

Which penicillins cover ONLY gram + anaerobes?

Gram + anaerobes—> Regular penicillins, Aminopenicillins

Which penicillins cover BOTH gram + and gram -anaerobes?

PCN/B lactamase inhibitor

Which penicillines cover enterobacterales (gram -)

PCN/B lactamase inhibitor

Of the penicillins, only the _____ class has good gram negative coverage

PCN/B lactamase inhibitor

Which penicillin antibiotic covers pseudomonas

Piperacillin/tazobactam

First generation Cephalosporins

Cefazolin, Cephalexin , Cefadroxil

Secind gen cephalosporins

Cefuroxime-axetil, Cefaclor, Cefprozil,

Cephamycins: Cefoxitin, Cefotetan (active against gram- anaerobes)

Third Generation cephalosporins

V: Cefotaxime, Ceftazidime, Ceftriaxone, Ceftolozane

Oral: Cefdinir, Cefditoren, Cefixime, Cefpodoxime, Ceftibuten

Fourth generation cephalosphorin

Cefepime

5th Generation cephalosporin

Ceftaroline

First Generation Cephalosporins Spectrum

Strep, MSSA, G+ anaerobes

What coverage is added in second gen cephalosphorins?

(Same coverage as first gen)

AND

Gram negatives: Enterbacterales, H/influe

AND Gram negative anaerobes FOR CEFOXOITIN + CEFOTETAN

Third gen cephalosporin coverage

Gram negative rods (no gram positives)
Ceftazidime—> Psuedomonas too
Ceftriaxone—> Gram positives too

4th gen ceph (Cefipime) Coverage

MSSA, Strep, Pseudomonas, Gram - rods

5th gen cephalosporin coverage (Ceftaroline)

MSSA, MRSA, Strep, Gram- rods

Carbapenems

Imipenem

Meropenem

Ertapenem

Carbapenem Spectrum

Good: MSSA, Strep, Anaerobes, Enteric GNRs, Pseudomonas (not erta), ESBLs (Extended-spectrum beta-lactamase)

Empiric treatment of choice for ESBL

Monobactam

Aztreonam

Good: Pseudomonas, most GNRs

Poor: Gram+ anaerobes

This B lactam can be used safety in hypersensitivity to other B lactams

What beta lactams do not need renal adjustment

Oxacillin, Nafcillin, Dicloxacillin

Ceftriaxone

What antibtiotics from this lecture cover pseudomonas

Piperacillin/tazobactam

Ceftazidime

Cefepime

Imipenem, Meropenem

Aztreonam

What antibtiotics from this lecture cover MRSA

Ceftaroline