B Lymphocytes

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19 Terms

1
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What 2 Lymphocytes mediate the Adaptive (Specific) Immune Response?

  • B & T Lymphocytes

2
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Where are B lymphocytes created?

  • Bone marrow

3
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B lymphocytes primarily combat?

  • Bacterial Infections

  • and some viral.

4
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B lymphocytes are said to have?

  • Humoral Immunity

  • Meaning they Secrete Antibodies into the Blood & Lymph Circulation

5
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These antibodies circulate around the body and will bind to their target?

  • Bind to their target Antigen

  • Initiating Opsonisation 

6
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B lymphocytes are only activated when?

  • Exposed to the specific Antigen

7
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Once activated B Lymphocytes can?

  • Proliferate
    - Vast Cellular Replication

8
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Each B- lymphocyte produces a single species of?

  • Antibodies

9
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Each antibody has a unique antigen…?

  • Antigen Binding Site

10
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Plasma Cells produce?

  • Proteins and secrete them into circulation.

  • 2,000 Antibodies per second

11
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Once a circulating antibody binds to the antigen on the pathogenic cell surface and activates the complement system it can result in?

  • Membrane Attack Complex

  • Opsonisations

  • Neutralization

  • Agglutination

12
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What is Opsonisation?

  • Labelling a target cell for Phagocytosis

13
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What is Membrane Attack Complex?

  • Insertion of large holes in the cellular membrane disrupting the pathogens ability to regulate
    its internal environment

14
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What is Neutralisation ?

  • Huge amount of antibodies can bind to the pathogen,

  • completely covering its surface which inhibits pathogen movement and infectivity

15
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What is Agglutination?

  • Antibodies can clump pathogenic cells together inhibiting movement

  • and making destruction of the pathogenic cells easier for macrophages

16
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Active Immunity develops when?

  • When the body produces its own response to An Pathogen/Antigen

17
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Describe Primary Response in relation to Active Immunity?

  • 1st Time body encounters the Pathogen/ Antigen

  • Response time to produce Antibodies is slow.

  • Antibody once made is synthesized and ready for replication

18
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Describe Secondary Response in relation to Active Immunity?

  • Within a day a high concentration of antibodies is detectable.

19
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What is Passive Immunity?

  • Immune Protection through Transfer of Antibodies.

  • From a Non-Endogenous Source.