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Number of Parent Cells in Mitosis
1
Number of Parent Cells in Meiosis
1
Parent Cells in Mitosis
Diploid
Parent Cells in Meiosis
Diploid
Type of Cells in Mitosis
Somatic (Body Cells)
Type of Cells in Meiosis
Gametes (Sex cells, egg, sperm)
Number of Daughter Cells in Mitosis
2
Number of Daughter Cells in Meiosis
4
Daughter Cells in Mitosis
Diploid
Daughter Cells in Meiosis
Haploid
Purpose of Mitosis
Asexual reproduction for cell growth, repair and development by producing TWO identical daughter cells
Purpose of Meiosis
Sexual reproduction to produce gametes with half the chromosomes of the parent cell
Human chromosome number (Body Cell)
46
Human chromosome number (Gametes)
23
Male Gametes
Sperm
Female Gametes
Egg/Ovum
Fertilization
Joining of the egg and sperm
Why half the chromosomes?
So that fertilization can occur which restores the normal chromosome number in the offspring
Somatic/Body Cells are produced in 2 ways
Mitosis
Zygote through fertilization (First Body Cell)
Diploid (2n)
Normal chromosome number for an organism that is found in body or somatic cells (or in the zygote)
Haploid (n)
HALF the normal chromosome number, found ONLY in gametes or sex cells
23 individual chromosome (NO PAIRS)
Homologous chromsomes
Pairs (2n) of chromosomes with the same gene location
NOT IDENTICAL to each other (each is n)
Are similar: one from mother (n) and one from father (n) - together form a 2n pair!
Interphase
Growth and Development stage
IMPORTANT: Chromosomes replicate forming sister chromatids
Meiosis 1
Division of nucleus (P1, M1, A1, T1)
SEPARATION OF HOMOLOGOUS PAIRS
Interkinesis
Division of cytoplasm and organelles to form 2 cells
Meiosis 2
Division of nucleus (P2, M2, A2, T2)
Separation of sister chromatids
Cytokinesis
Division of cytoplasm and organelles to form 4 cells
“Crossing Over” in Tetrads (Prophase 1)
Non-sister chromatids (Mom and Dad chromosomes) exchange genetic information
Chromosomes formed are different from the original
Leads to variation and diversity in offspring
Gametogenesis
Forming gametes
Human Spermatogenesis
Formation of 4 sperm
Occurs in 2 testes or reproductive organs
Human Oogenesis
Formation of 1 egg (ovum) and 3 polar bodies that die
Occurs in 2 ovaries or reproductive organs
Polar bodies
A cell separates from the immature ovum during meiosis and cannot be fertilized (typically die)
Genotype
Gene that code for a trait
Phenotype
Trait that is shown
Physical expression of genes, outward appearence
Allele
Alternate version of genes
Accounts for variations in inherited characters
Different alleles vary somewhat in the sequence of nucleotides at the specific locus of a gene
Allele Set
True Genetic makeup of the chromosome
(Eye Color - Trait) (Red, white - Alleles)
P1 Generation
First Parents
F1 Generation
First offspring/1st gen (children)
F2 (Fn)
Second set of offspring (grand)/2nd gen
Test Cross
Crossing an unknown genotype (dominant phenotype) with a known recessive
Punnett Square
A table to help us see the genetic probabilities of a cross
Trait
Characteristic, Feature
Incomplete dominance
Hybrid is a blend of traits
Example:
Fr = Red
Fw = White
FrFw = PINK
The heterozygous creates a third phenotype
Every genotype has its own
phenotype
If both alleles are present and the two alleles differ
Then the dominant allele is fully expressed in the organism’s appearance
The other recessive allele has no noticeable effect on the organism’s appearence
Only see recessive if it is a
double recessive
Homozygous
2 of the same alleles
BB=Dominant, bb=recessive
Heterozygous
Hybrid condition
2 different alleles
Bb appears dominant
Normal vision female
XCXC
Carrier female (Heterozygous)
XCXc
Color blind female
XcXc
Normal vision male
XCY
Colorblind male
XcY
A is dominant over
O
B is dominant over
O
AB is
codominant
Blood type A (Phenotype)
AA or AO (Possible Genotypes)
Blood type B (Phenotype)
BB or BO (Possible Genotype)
Blood type AB (Phenotype)
AB (Possible Genotypes)
Blood type O (Phenotype)
OO (Possible Genotype)
With RH
Positive
Without RH
Negative
Polygenic Traits
Many genes make up the final appearence
Examples include skin, eye, hair color
Karyotype
Arranging homologous pairs from largest to smallest excluding the sex chromosomes
Autosomes
#1-22 for all traits except sex
Sex chromosomes
Pair #23 XX (Female) or XY (Male)
Nondisjunction
Chromosomes fail to “disjoin” or separate
Trisomy
Zygote with 3 of ONE Type of Chromosomes
Monosomy
Zygote with 1 of one type
Down Syndrome has
3 #21 Chromosomes
Klinefelter’s Syndrome
has an extra X chromosome
Turner Syndrome
Has only one X chromosome
XO sex chromosome instead of XX female or XY for male
Law of Dominance
Example of simple inheritance where dominant allele is expressed and recessive is masked. Can occur on autosomes or sex chromosomes (X and Y)
Incomplete Dominance
When one dominant allele and one recessive allele are inherited from either parent, the heterozygous offspring will exhibit a blending of those two alleles
Codominance
Expression of both alleles at the same time. Phenotypes of both homozygous traits are equally expressed in the offspring.
Sex linked traits
Traits controlled by genes located on sex chromosomes (Colorblindness and hemophilia, these conditions are recessive to normal vision and blot clotting)
Multiple alleles
Traits are controlled by more than two ALLELES (Three for Blood Types, or Four alleles of a single gene, control fur coat color in rabbits)
Pedigree
Graphic representation of an individual’s family tree, which permits patterns of inheritance to be recognized
A dominant pedigree is either
Shaded or not shaded in
A recessive pedigree has
heterozygous (Half Shaded in)
Mendel’s Law of Segregation
the parental genes must separate randomly and equally into gametes during meiosis so there is an equal chance of the offspring inheriting either allele. No allele is favored or has an advantage over another.
Mendel’s law of independent assortment
Inheriting an allele has nothing to do with inheriting an allele for any other trait. The alleles from parents are passed on independently to the offspring. After fertilization, the resulting zygote(s) can end up with any combination of chromosomes
Organ that produces egg cells
Ovaries