Citric acid cycle

Where does the citric acid cycle occur?

mitochondria matrix

Pyruvate moves from the cytosol to the mitochondria via

mitochondrial pyruvate centers

Inside the mitochondria, pyruvate gets worked on by ...

the pyruvate dehydrogenase complex

pyruvate dehydrogenase complex converts 2 pyruvate into

2 acetyl CoA, 2 CO2, 2 NADH

Step 1 of Citric Acid Cycle

Acetyl-CoA + oxaloacetate to citrate

What enzyme converts Acetyl-CoA + oxaloacetate to citrate?

citrate synthase

Step 2 of the citric acid cycle

citrate to isocitrate

What enzyme converts citrate to isocitrate?

aconitase

Step 3 of the citric acid cycle

isocitrate to alpha-ketoglutarate;

NAD+ to NADH

what enzyme converts isocitrate to alpha-ketoglutarate?

isocitrate dehydrogenase

Step 4 of the citric acid cycle

alpha ketoglutarate + CoA to succinyl-CoA; gives off CO2; NAD+ to NADH

Step 5 of the citric acid cycle

succinyl-CoA to succinate + CoA; GTP +ADP to GDP + ATP

What enzyme converts succinyl-CoA to succinate + CoA?

succinyl-CoA synthase

What enzyme converts GTP +ADP to GDP + ATP?

nucleoside diphosphate kinase

Step 6 of the citric acid cycle

Succinate to fumarate; FAD to FADH2

What enzyme converts Succinate to fumarate?

succinate dehydrogenase

Where does step 6 (Succinate to fumarate) take place?

inner leaf of the inner mitochondrial membrane

Malonate is a competitive inhibitor of ...

succinate dehydrogenase

Step 7 of the citric acid cycle

fumarate + water to malate

Step 8 of the citric acid cycle

malate to oxaloacetate; NAD+ to NADH

End products of the citric acid cycle

2 CO2, 1 GTP, 1 FADH, 3 NADH

High ATP, High NADH levels

Shuts down the citric acid cycle

Low ATP, Low NADH

speeds up the citric acid cycle