BPH

Testosterone is metabolized to what by 5 alpha reductase

dihydrotestoeterone (DHT)

what form of testosterone is respobible for the normal/hyperplstic grwoth of prostate

DHT

Testosterone is metabolized to what by 5 alpha reductase

dihydrotestoeterone (DHT)

what form of testosterone is respobible for the normal/hyperplstic grwoth of prostate

DHT

Drugs that worsen BPH

centrally acting anticholinergis, anithcholinergic drugs, caffien, diuretics, snris, testosterone products

LUTS

Hesititancy, intermittent urine flow, staringin or weak stream, urinary urgency/leaking/dribbling, urinary frequency/noceturia, incomplete emptying f the bladder, bladder outlet obstrutcts.

what questionairs for bph

AUSS, IPSS

treatment mild disease

watchful waiting

treatment mod/severe disease

meds or TURP

natural products

saw palmetoto, pygeum, pumpkin seed, rye pollen, lycopene

5 alpha-reductase inhibitors work by;

decreasing prostate size

alpha blockers work by

dont shrink prostate; inhibit alpha 1 arenergic receptors, causing relxation of smooth muscle in pratrate bladder/neck

alpha-1a

prostate

alpha 1b/1d

heart and arteries

non selective alpha blockers

terazosin, doxazoin

selective alpha 1a blockers

tamsulosin, afluzosin, dildosin

what med puts you at risk for intraoperative flopy iris syndrome (IFIS)

alpha blockers

doxazosin generic

cardura, cardura xl

take doxazosin/terzosin when

at bedtime

tamsulosin

flomax

tamusolsin + dutasteride

jalyn

alfuzosin

uroxatral

sioldosin

rapaflo

ci; alpha blockers

silodosin/alfuzosin with strong CYP3A4 inhits; hepatic imapriemnt (C for sildosin, b/c alfuzolin); severe renal impariemtn silodsin

alpha blockers; se

orthosttatis hypotension, IFIS, priapsism, angina, dinzziness, faitue, ehadache, abnormal ejaculation, fluid retetion, rhinitis

how long does it take for alpha blockers to assess whether they are acutally benefitical

4-6 weeks

5 alpha reducase inhibitors

finasterid, dutasteride

finasteride is selective for what

type ii enzyme (more localized to prostate)

finasteride

proscar, propecia (alopecia)

tadalafil + finasteride

entadfi

dutasteride

avodart

5 alpha reducase inhib ci

women of child bearing pottention, preganncy, children

5 alpha reductase inhib warnings/side effects

increase risk prostate cancer; impotence, ejaculation distrubance, breast enlargement and tenderness, rash,

how long dose it take for 5 alpha reductase inhibitors to work

6 months

what can tadalafil NOT be used wtih

alpha blockers