CCBs → sub class: Dihydropyridines -pine

Drugs in class

verapamil (Calan)

diltiazem (Cardizem)

nifedipine (Adalat)

nimodipine (Nimotop)

Properties/MOA

·       ↓ contractility

·       ↓ AV node conduction

Vasodilation

Effects/Adverse Rxn

·       Bradycardia

·       Hypotension

·       Dizziness

·       Gingival hyperplasia

·       Constipation

·       Congestive heart failure (due to ↓ contractility)

·       Edema

Reflex tachycardia

Contraindications

Ø  ♥ block

Ø  CHF

Ø  Hypotension

Impaired renal or liver function

Nursing Info.

·       Check HR and BP, & ♥ block

·       Used for HTN, angina, vasospasm (nimodipine)

·       ↓ AV node conduction:

→ verapamil, diltiazem

·       Promotes vasodilation:

→ nifedipine, nimodipine

·       nimodipine indicated for subarachnoid hemorrhage vasospasm. The only indication for this drug!

Use w/caution in other drugs that ↓ AV node conduction (digoxin or β blockers)