NARCAN DRUG PROFILE

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Last updated 2:10 AM on 7/30/26
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9 Terms

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Drug classification

Opiate antagonist/ Antitode

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Mechanism of action

Competitive Opiate Receptor Antagonist —> displaces narcotic molecules, has greater affinity for receptor site, but shorter duration

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Pharmacokinetics

onset of action: 2-10 mins

peak effects: 2-10 minutes

duration of effect: 20-120 minutes

Half-life = 60-90 minutes

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Indications/Field use

Respiratory depression caused by narcotics/opiates

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Contraindications

None

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Side effects/adverse reactions

Hypotension, hypertension, nausea, vomiting, seizures, dysrhythmias

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Dose and Route

Adult: 2-4 mg IN, q 3-5 minutes with max 2 doses

Pedi: 2-4 mg IN, q 3-5 minutes with max 2 doses

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Precautions

May induce withdrawal in newborn infants with addicted mothers

Oral opiates may require higher doses of naxolane for reversal

After second dose consider calling medical control if breathing remains inadequate

Patients may wake up combative

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Drug to Drug Interactions

May Induce withdrawal on opiate-dependent patient