1.4 Growth Hormone Pathway

Draw Growth Hormone Pathway

Long Term Effects

Controlled by IGF Hormone. IGF stimulates bone, muscle, carilage, and cell growth as well as protein synthesis for tissue regeneration.

Short Term Effects

Controlled by Growth Hormone. GH stimulates fat and carbohydrate breakdown and release as well as release of stored glucose. Glucose and Fats in blood used to make ATP.

Why Do Teenagers have Leaner Mass?

Higher GH in youth caues muscle tissue growth and stimulates fat breakdown

Why do athletes want to take excess GH?

To improve performance. Increase GH, Increase IGF, Increase GHIH. This causes more fat breakdown and increase cartilage, bone, and muscle growth.

Why does wound healing take longer in elderly?

Takes longer to heal wounds since GH is lower as we age which lowers IGF. So tissue regeneration is slower.

Growth Hormone Pathologies: Pituitary Gigantism

Pituitary adenoma appears ealy in life when epispyseal plate not fused so long bones grow and patient grows taller.

Pituitary Gigantism Blood Levels

• Low GHRH

• High GHIH

• High GH

• High IGF

Pituitary Gigantism Treatments

Remove the tumor and GHIH Drug Therapy

Acromegaly

Pituitary Adenoma appears when epipyseal plate fused so bones get thickers causing patient hands and feet to enlarge

Acromegaly Blood Levels

• Low GHRH

• High GHIH

• High GH

• High IGF

Acromegaly Treatment

Remove Tumor and GHIH Drug Therapy

Laron Syndrome

Genetic Defect where the mutations in GH receptor in Liver

Laron Syndrome Blood Levels

• High GHRH

• Low GHIH

• High GH

• Low IGF