Outline of Inflammation

These flashcards cover essential topics related to inflammation, including signs, mediators, and physiological changes.

What are the cardinal signs of inflammation?

Calor (heat), Rubor (redness), Tumor (swelling), Dolor (pain), Functio laesa (disturbed function).

What are the two major groups of mediators of inflammation?

Plasma derived and Cell derived.

What physiological change occurs first during inflammation?

Transient constriction of arteriolar smooth muscles followed by vasodilation.

What is active hyperemia in the context of inflammation?

It refers to increased blood flow to the affected tissue.

What is edema in response to circulatory changes?

Increased hydrostatic pressure leading to fluid accumulation in tissue.

What happens to red blood cells during hemodynamic changes in inflammation?

RBCs may form rouleaux and experience margination.

What is the role of mediators of inflammation?

They are biochemically diverse substances that act on many cells and tissues during the inflammatory response.

Which factors are involved in the pathogenesis of inflammation?

Circulatory changes, mediators of inflammation, and cellular events.

What can be classified under pathologic forms of inflammation?

Different types of inflammation that deviate from the normal healing process.

What is the importance of clinicopathologic correlations in inflammation?

They help correlate clinical signs and symptoms with underlying pathological changes.