4430 Pharmacology Flashcard Set 1

Name a somatostatin analog used to suppress growth-hormone excess.

Octreotide
(Acromegaly and other hormone-secreting tumors; acute control of bleeding esophageal varices.)

Name a luteinizing hormone (LH) analog.

Lutropin

(Triggers final oocyte maturation and ovulation during controlled ovarian stimulation; male hypogonadotropic hypogonadism.)

Name a follicle-stimulating hormone (FSH) analog.

Folitropin Alpha

(Controlled ovarian hyperstimulation in women; infertility from hypogonadotropic hypogonadism in men.)

Which recombinant hormone is used as a growth-hormone agonist for replacement therapy?

Somatropin

(Growth-hormone deficiency, certain causes of short stature in children, HIV-associated wasting, and short-bowel syndrome.)

Folitropin Alpha is used as an agonist for what hormone?

follicle stimulating hormone

(FSH-receptor agonist)

Mecasermin is an agonist that replaces which growth factor?

IGF-1

(a recombinant form of IGF-1)

Which recombinant drug acts as an IGF-1 agonist?

Mecasermin

(IGF-1 deficiency that does not respond to exogenous growth hormone.)

Which drug is a synthetic form of human GnRH?

Gonadorelin

(Diagnostic testing of gonadotropin function and induction of ovulation.)

Bromocriptine lowers prolactin by acting as an agonist at which receptor?

Dopamine receptor

(Dopamine D2-receptor agonist, which inhibits prolactin secretion.)

Octreotide and lanreotide are analogs of which hormone?

somatostatin

(somatostatin-receptor agonist)

Which drug is a vasopressin receptor antagonist?

Conivaptan

(Hyponatremia in hospitalized patients.)

Name a GnRH receptor antagonist

Ganirelix (and Cetrorelix and Degarelix)

(Prevents premature LH surges during controlled ovarian stimulation; degarelix and abarelix are used in advanced prostate cancer.)

Which dopamine agonist is used to lower prolactin?

Bromocriptine

(Hyperprolactinemia and Parkinson disease.)

Which drug activates oxytocin receptors to induce labor?

Oxytocin

(Induction and augmentation of labor; control of postpartum uterine hemorrhage.)

Atosiban is an antagonist at which receptor?

Oxytocin Receptor

(Blocks oxytocin receptors, reducing uterine contractions.)

Conivaptan is an antagonist at which receptor?

Vasopressin receptor?

Pegvisomant blocks the receptor for which hormone?

growth hormone

(Blocks signaling at the GH receptor.)

Which drug is a gonadotropin-releasing hormone (GnRH) receptor agonist (analog)?

Leuprolide (as well as Gonadorelin, Histrelin, Nafrelin, Triptorelin, and Goserelin)

(Ovarian suppression, central precocious puberty, endometriosis, and advanced prostate cancer.)

Somatropin acts as an agonist at receptors for which hormone?

Growth Hormone

(A recombinant form of human growth hormone that acts through GH receptors to increase production of IGF-1.)

Leuprolide is an agonist analog of which hypothalamic hormone?

GnRH

(GnRH-receptor agonist; continuous (non-pulsatile) exposure ultimately suppresses gonadotropin release.)

Gonadorelin is a synthetic form of which hypothalamic hormone?

GnRH

(GnRH-receptor agonist.)

Which drug is a growth-hormone receptor antagonist?

pegvisomant

(Acromegaly.)

Which drug is a vasopressin (V2) receptor agonist?

Desmopressin

(Central (pituitary) diabetes insipidus, hemophilia A, and von Willebrand disease.)

Desmopressin is an agonist at which vasopressin receptor?

V2 receptor

(Agonist at vasopressin V2 receptors, promoting water retention.)

Human chorionic gonadotropin (hCG) acts as an agonist analog of which hormone?

luteinizing hormone

(LH-receptor agonist.)

Oxytocin is an agonist at which receptor?

Oxytocin receptor

(Oxytocin-receptor agonist that stimulates uterine contraction.)

Name an oxytocin receptor antagonist used as a tocolytic.

Atosiban

(Tocolysis to delay preterm labor.)

Ganirelix is an antagonist at receptors for which hypothalamic hormone?

GnRH

(Blocks GnRH receptors, immediately suppressing gonadotropin release.)