Enterobacteriaceae & Shigella

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8 Terms

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Enterobacteriaceae family

Gram-negative•

Facultative anaerobes•

Motility is variable•

Fecal-oral transmission

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Enterobacteriaceae types

O antigen (outermostpolysaccharide of LPS)•

K antigen (capsule)•

H antigen (flagella)

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Enterobacteriaceae toxins

enterotoxin - produces net

cytotoxins

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Shigella

Non-motile, exceptactin-based motility

facultative anaerobic

oxidase negative

catalase positive

cause shigellosis

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Shigellosis

Most infections are in children under 4 yr

Shigella dysenteriae developing countries

Shigella sonnei developed countries(USA)

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Shigellosis pathology

Bloody, mucoid diarrhea

Large intestine

Dehydration

Pyroptosis

Macrophage death

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Shigella virulence factors

encoded by plasmid: invasion plasmid antigen (IPA) + outer surface protein (OSP) -> motility and secretion

chromosomal pathogenic islands (PAIs): toxins, antibiotic resistance, iron uptake

Mix-Par type III secretion system (Ipa)

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Shigellosis treatment

Supportive care•

Uncommon antibiotics•

No antidiarrheal agents