Enterobacteriaceae & Shigella
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8 Terms
Enterobacteriaceae family
Gram-negativeā¢
Facultative anaerobesā¢
Motility is variableā¢
Fecal-oral transmission
Enterobacteriaceae types
O antigen (outermostpolysaccharide of LPS)ā¢
K antigen (capsule)ā¢
H antigen (flagella)
Enterobacteriaceae toxins
enterotoxin - produces net
cytotoxins
Shigella
Non-motile, exceptactin-based motility
facultative anaerobic
oxidase negative
catalase positive
cause shigellosis
Shigellosis
Most infections are in children under 4 yr
Shigella dysenteriae developing countries
Shigella sonnei developed countries(USA)
Shigellosis pathology
Bloody, mucoid diarrhea
Large intestine
Dehydration
Pyroptosis
Macrophage death
Shigella virulence factors
encoded by plasmid: invasion plasmid antigen (IPA) + outer surface protein (OSP) -> motility and secretion
chromosomal pathogenic islands (PAIs): toxins, antibiotic resistance, iron uptake
Mix-Par type III secretion system (Ipa)
Shigellosis treatment
Supportive careā¢
Uncommon antibioticsā¢
No antidiarrheal agents
Note 
Flashcards (25)