Pathogenesis of Fungal Diseases DD
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40 Terms
Opportunistic fungi will more likely infect patient associated with?
Immunosuppression, chemotherapy, transplants, and antibiotics
What kind of hyphae do most Candida species have?
Pseudohyphae
What species of Candida do not form pseudohyphae?
Candida glabrata
What species causes UTIs and is the second most common cause of fungemia?
Candida glabrata
TRUE or FALSE
Candida albicans has both yeast and pseudo-hyphal formsWhat
Candida albicans
What kind of infections are caused by Candida albicans?
Skin and Muco-cutaneous
Where are Candida albicans located?
Gastrointestinal mucosa, vaginal mucosa, skin, nail
What are the mode of infection for Candida albicans?
Catheter colonization and hematogenous dissemination
TRUE or FALSE
Candida albicans exhibit phenotypic switching
TRUE
Oral or vaginal thrush is caused by?
Candida albicans
What test is used to identify Candida albicans? A positive test will show growth of a continuous extension from the yeast cells and no septum exists.
Germ Tube Test
What species of yeast is multidrug resistant and causes bloodstream, wound, and ear infection?
Candida auris
What is the etiological agent of Cryptococcal meningitis?
Cryptococcus neoformans
Cryptococcus neoformans contains a prominent _____
capsule
How are Cryptococcus neoformans transmitted?
Pigeon droppings
TRUE or FALSE
Cryptococcus neoformans can survive intracellularly
TRUE
What temperature will growth occur?
37 C
What species causes meningitis?
Cryptococcus neoformans
What protects Cryptococcus neoformans from oxidative injury?
Capsule and melanin
Cryptococcus neoformans suspended in India ink will appear as round cells with a _____ _____
clear halo
Cryptococcus neoformans uses host epinephrine to produce?
Melanin
What species is a common cause of pneumonia in immunosuppressed patients?
Pneumocystis jirovecii
What species was previously classified as parasites?
Pneumocystis species
Where are Aspergillosis species found?
Dead leaves, compost pile, stored grain, marijuana leaves
TRUE or FALSE
Saprobic and parasitic phases of Candida albicans are the same
TRUE
TRUE or FALSE
Saprobic and parasitic phases of Cryptococcus neoformans are the same
TRUE
TRUE or FALSE
Saprobic and parasitic phases of Aspergillus species are the same
FALSE
Inhaled yeast cells of Cryptococcus neoformans are ingested by _____
macrophages
Inhaled condida of Aspergillus species bind to _____ and _____ in alveolus
fibrinogen, laminin
Vascular invasion of Aspergillus species results in?
Thrombosis and infarction of tissues
What is a highlighted predisposing factor to Mucormycosis?
Diabetes
What is associated with COVID-19?
Mucormycosis
What species are characterized by a lack of septa within their hyphae?
Mucor
Mucor have _____-like hyphae
ribbon
What species have septated hyphae that are uniform in diameter?
Aspergillus species
What is characteristic of the fruiting bodies of Aspergillus species?
Conidiphore covered with conidia
What species is associated with catalase?
Aspergillus
Hyphal forms of Aspergillus secrete _____ and invade epithelium
proteases
What species is transfer to wounds via contaminated tape and bandages?
Aspergillus species
What species are associated with catheter?
Candida albicans