VET-131 Hematopoiesis Quiz

Hematopoiesis

Production of blood cells & platelets

What is whole blood made of?

Plasma & cells (RBCs, WBCs, & platelets)

What are the 2 main types of WBCs?

Agranulocytes & granulocytes

Agranulocytes

Aka mononuclear leukocytes; no granules; lymphocytes & monocytes

Granulocytes

Aka polymorphonuclear leukocytes (PMNs); granules; neutrophils, eosinophils, & basophils

Qualities of blood cells

Are constantly produced & have a finite life span so they must be replaced

Where is the production of blood cells in the prenatal animal?

Liver, spleen, thymus, & red bone marrow

Where is the production of blood cells in the adult animals?

Red bone marrow

In stressed adult animals, where can blood cell production revert to?

Liver & spleen

Erythropoiesis

Production of erythrocytes (RBCs)

Leukopoiesis

Production of leukocytes (WBCs)

Thrombopoiesis

Production of thrombocytes (platelets); requires thrombopoietin & other cytokines

All blood cells arise from what cell?

Pluripotent hematopoietic stem cell

Cytokine of erythropoiesis

Erythropoietin; produced by kidney cells

What are immature RBCs that lose ribosomal material?

Reticulocytes

What is another name for a metarubricyte?

Nucleated RBC (nRBC)

Cytokine of thrombopoiesis

Thrombopoietin; produced in the liver

Cytokines of granulopoiesis

Leukopoietin & numerous others

Granulopoiesis

Production of granulated leukocytes

Monopoiesis

Production of monocytes

Lymphopoiesis

Production of lymphocytes; requires certain cytokines & antibodies

Pancytopenia

Decrease in numbers of all blood cells (RBCs, WBCs, & platelets)

Left-shift

Increased numbers of immature neutrophils

Leukemia

Neoplastic cells of blood or marrow

Leukemoid response

Can be mistaken for leukemia, characterized by marked leukocytosis (increased leukocytes), & is usually the result of inflammatory disease

-penia

Decreased number of cells

-philia or -cytosis

Increased number of cells

Stages of erythropoiesis

Pluripotent hematopoietic stem cell
Common myeloid precursor cell
> rubriblast
> prorubricyte
> rubricyte
> metarubricyte
> reticulocyte
> erythrocyte

Stages of granulopoiesis

Pluripotent hematopoietic stem cell
Common myeloid precursor cell
> myeloblast
> promyelocyte
> myelocyte
> metamyelocyte
> band cell
> granulocyte

Stages of monopoiesis

Pluripotent hematopoietic stem cell
Common myeloid precursor cell
> monoblast
> promonocyte
> monocyte

Stages of lymphopoiesis

Pluripotent hematopoietic stem cell
> common lymphoid precursor cell
> lymphoblast
> prolymphocyte
> B-lymphocyte or T-lymphocyte

Stages of thrombopoiesis

Pluripotent hematopoietic stem cell
Common myeloid precursor cell
> megakaryoblast
> promegakaryocyte
> megakaryocyte
> thrombocyte

What is the most immature cell in the granulocyte series?

Myeloblast

What is the precursor cell to thrombocytes?

Megakaryocytes

What do we normally call reticulocytes on blood smears?

Polychromatophilic RBC