Antibodies and antigen receptors

What is the central tenant of the humoral immune response?

Antibody production

Immunoglobulins (Ig)

Glycoprotein molecules which are produced by plasma cells in response to an immunogen and which function as antibodies

The largest spike in serum proein electrophroesis is:

albumin

What spike in the serum protien electrophoresis correlate to immunoglobvulins

gamma

valency

the number of antigenic determinants that an individual antibody molecule can bind to

True or False: The valency of all antibodies is at least two.

TRUE

What are the three main effector function sof antibodies?

• bind antigens or toxins and neutralize particles

• opsonins

• activation of the classical complement cascade

Variable regio

consists of both heavy and light chains and contains the antigen binding site (Fab)

COnstant region

consists of two heavy chains and determines the antibody's biological role (Fc).

Idiotope

smaller specific sites that bind to the antigen epitope

What are the 5 isotypes of antibodies?

IgM

IgD

IgG

IgE

IgA

IgG and IgM are considered

systemic antibodies

Where is IgG found?

tissues throughout the body

Where is IgA found?

mucosal antibody

Where is IgE found?

cutaneous

isotype switch

a genetic recombination process in B cells that changes an antibody from the default IgM type to another antibody type (isotype), such as IgA, IgG, or IgE

hat part of the antigen is isotype switch invovled in?

Constant region is the one thaty changes

Wha does IgD do?

receptor on naive B cells

• enhances mucosal immunity

• pro-inflammatoryu

IgM function

• BCR on naive B cells

• activates complement

True or False: IgM is typically found in a pentameric form, giving it multiple binding sites

TRUE

What is the most abundant isotype in mammals?

IgG

Functions of IgG

• activates compliment

• antibody dependent cell-mediated destruction

True or False: IgG is responsible for clumping of a pathogen togethe

TRUE

What is the best opsonizing antibody?

IgG

What does IgA do?

• prevents microbial attachment

• prevents toxin attachment

• IN THE MUCSA

What allows IgA to b transported across mucosal surafces?

J-chain

hat is IgE associated with?

allergic and parasitic infections

• mast cell and eosinophil mediation

Which is the largest antibody?

IgMW

Which is the smallest antibody?

IgG and IgD