Amphetamine/Dextroamphetamine T300 26-27

Amphetamine/Dextroamphetamine

Adderall, Mydayis

Amphetamine/Dextroamphetamine Drug Class

CNS Stimulant, C-II

Amphetamine/Dextroamphetamine Dosage Forms

Oral Tablet: 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, 30 mg
Oral Capsule, Extended Release: 5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, 25 mg, 30 mg, 37.5 mg, 50 mg

Amphetamine/Dextroamphetamine Dosing By Indication

1. Attention deficit hyperactivity disorder: Adults, extended release, 20 mg po daily; Children, immediate release (3–5 y of age), initial 2.5 mg po daily in am; extended release (≥6 y of age), initial 10 mg po daily in am
2. Narcolepsy: Adults, immediate release, 5–60 mg/d po in divided doses; Children, immediate release (6–12 y of age), initial 5 mg po daily; immediate release (≥12 y of age), initial 10 mg po once daily

Amphetamine/Dextroamphetamine Off Label Uses

None

Amphetamine/Dextroamphetamine MOA

Non-catecholamine sympathomimetic amines with CNS stimulant activity. This drug blocks the reuptake of norepinephrine and dopamine into the presynaptic neuron and increases the release of these monoamines into the extraneuronal space.

Amphetamine/Dextroamphetamine Common Adverse Effects

Hypertension, weight loss, loss of appetite, xerostomia, headache, insomnia

Amphetamine/Dextroamphetamine Efficacy Monitoring Parameters

Resolution of signs of ADHD with improved attention span and reduced impulsivity.

Amphetamine/Dextroamphetamine Safety Monitoring Parameters

BP, heart rate, weight; chest pain, seizures, heart palpitations, changes in behavior or personality, hostility.

Amphetamine/Dextroamphetamine Key Counseling Points

Avoid late evening doses due to insomnia. Extended-release capsules may be swallowed whole with or without food. Capsule contents may be sprinkled on applesauce and consumed immediately without chewing; consume entire contents. Do not divide the dose of a single capsule.

Amphetamine/Dextroamphetamine Clinical Pearls

Amphetamines have a high potential for abuse and prolonged use may lead to dependence. Misuse may cause sudden death and serious cardiovascular adverse events. Not recommended for weight loss. Product exists as a combination of amphetamine salts including amphetamine aspartate, amphetamine sulfate, dextroamphetamine aspartate, and dextroamphetamine sulfate