complement system L7

what is the complement system?

a set of serum proteins that act in a cascade to attack and kill extracellular pathogens

approx how many components to the complement system?

30

whats the inactive form of the proteins in the liver?

zymogene

how is the complement system activated?

by proteolytic cleavage

what are the three main functions of the complement system?

1. to opsonise pathogens and promote phagocytosis

2. to generate pores in bacterial membranes

3. inflammatory response

complement system is made up of _______ and _____ ______

glycoproteins

soluble proteins

soluble proteins and glycoproteins circulate as ________ _____

inactive proenzymes

proteolytic cleavage does what?

removes inhibitory fragments and exposes active site

the nomenclature of the complement system is designated by ?

numerals and letter symbols

C_ to C_, factor , and ______ restriction factor

1-9

D

homologous

large fragments are denoted as?

b

small fragments are denoted as?

a

complements unique to the alternative pathway, as well as regulatory proteins are denoted by ?

uppercase letters, ie B and D

cleavage products are denoted by?

lowercase letters ie a and b