Squamous cell carcinoma (SCC)

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6 Terms

1
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Development of SSC Light Skin (4)

  1. UV OR Carcinogens, Chronic ulcers, Burn scar, Ionizing radiation →

  2. Loss of function mutation in TP53 →

  3. Activating mutation in HRAS →

  4. Invasive SCC (invades the dermis)

2
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Development of SSC Dark Skin (3)

  1. Keratinocytes →

  2. Carcinogens, Chronic ulcers, Burn scar, Ionizing radiation →

  3. Invasive SCC (invades the dermis)

3
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Histological Changes of SSC (2)

  1. Keratin pearls

  2. Carcinoma invaded the dermis

<ol><li><p><span style="font-family: &quot;Times New Roman&quot;, serif">Keratin pearls</span></p></li><li><p><span style="font-family: &quot;Times New Roman&quot;, serif">Carcinoma invaded the dermis</span></p></li></ol><p></p>
4
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Clinical features of SSC Light Skin

  1. Nodule

  2. Prominent keratinization (Scales) 

  3. Central ulceration

  4. Metastasis to lymph node

<ol><li><p><span style="font-family: &quot;Times New Roman&quot;, serif">Nodule</span></p></li><li><p><span style="font-family: &quot;Times New Roman&quot;, serif">Prominent keratinization (Scales)&nbsp;</span></p></li><li><p><span style="font-family: &quot;Times New Roman&quot;, serif">Central ulceration</span></p></li><li><p><span style="font-family: &quot;Times New Roman&quot;, serif">Metastasis to lymph node</span></p></li></ol><p></p>
5
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Clinical features of SSC Dark Skin

  1. Flat, scaly, dark plaque

<ol><li><p><span style="font-family: &quot;Times New Roman&quot;, serif">Flat, scaly, dark plaque</span></p></li></ol><p></p>
6
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Clinical features of SSC oral

  1. Ulcer, nodule or plaque

<ol><li><p><span style="font-family: &quot;Times New Roman&quot;, serif">Ulcer, nodule or plaque </span></p></li></ol><p></p>