Gout Treatment

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6 Terms

1
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What is the prototype?

Allopurinol

  • Given PO or IM

2
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Why is it prescribed?

Prevention of gout attacks if taken daily

3
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How does it work?

Interferes with uric acid production

4
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What happens if there is too much drug effect (5)?

Immune system suppression, renal impairment, skin reactions, Stevens-Johnson syndrome, and cataracts with long-term therapy (i.e., over 3 years)

5
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What is important to remember about this medication (10)?

  • Monitor

    • CBC (i.e., for bone marrow suppression/WBCs)

    • Kidney function

    • Skin assessment

    • Uric acid level

  • Caution

    • Asians, Pacific Islanders, and African Americans due to genetic risk factors

    • Pregnancy/lactation (i.e., risk vs reward)

    • Renal/hepatic impairment

  • DI:

    • ASA and bismuth sub salicylates (i.e., Pepto Bismol)

    • Warfarin requires higher doses to reach the anticoagulation goal

    • Theophylline increases risk of toxicity

6
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What do you need to tell a patient taking this medication (3)?

Report s/s of infection, bleeding/bruising, and blurry vision