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Describe diffusion
Location A has lower concentration of particles; Location B has higher concentration
More particles will diffuse from a region of high concentration to a region of low concentration
Particles diffuses from B to A, down the concentration gradient
Describe osmosis
Location A has low water potention; Location B has high water potential
Water molecules will move from a region of higher water potential to region of lower water potential
Water diffuses from B to A through partially permeable membrane by osmosis
Describe active transport
Location A has lower concentration of particles; Location B has higher concentration
Particles move through protein carriers on cell membrane,
from a region of low concentration to a region of high concentration,
using energy from respiration
Particles move from A to B, against the concentration gradient
Describe enzyme action
Enzyme is a biological catalyst that speeds up the chemical reaction
Substrate will bind to the active site of the enzyme, forming enzyme-substrate complex
the shape of the active site of enzyme is complementary to the substrate
the specificity of enzymes to substrate is like a lock and key
product will form from the enzyme-substrate complete after the reaction is completed
Enzyme will remain the same after the reaction
Describe the digestion of food through the alimentary canal
Food is ingested at mouth
Teeth break down food mechanically via chewing & crushing
Saliva contains amylase which helps to digest starch to maltose
Peritalsis push food bolus down the oesophagus
Stomach churning will break food further
Protease & pepsin breaks down protein to amino acids
In small intestines, trypsin breaksdown protein,
Bile emulsify fats & oils to increase surface area for chemical digestion
Lipase breaks down fats & oils to glycerol and fatty acids
Maltase breaks down maltose to glucose
Digested nutrient will be absorbed from intestines into blood
Large intestines further absorb water from undigested mass
Absorbed nutrients will assimilate and use by cells
Undigested food will be removed via egestion as faeces
Outline the pathway taken by water through the root, stem and leaf
Water & mineral ions absorbed through root hair cells
Water enter via osmosis
Mineral ions enter via active transport
Water then pass through root cortex cells into xylem
Water moves upwards in the xylem due to transpiration pulls
Transpiration pulls draw up a column of water molecules held together by forces of attraction between the molecules
Water in the xylem enter mesophyll cells for photosynthesis
Describe the functioning of the heart
Deoxygenated blood enters the right atrium via the vena cava
Atrium muscles contract, blood moves through the atrio-ventricular valve into the right ventricle
The right ventricle muscles contract and blood leaves via the pulmonary artery, towards the lungs
Oxygenated blood enters the left atrium via the pulmonary vein
The muscles of the left atrium contract and it moves through the atrio-ventricular valve into the left ventricle
The left ventricle muscles contract and blood then leaves the heart via the aorta, where it goes to the rest of the body to supply oxygen
Finally, it returns again to the heart via the vena cava, and the cycle continues.
Describe the process of clotting
The is a cut in blood vessel
Platelets coagulate at cut and form a temporary plug
Platelet release enzyme, turning soluble fibrinogen into insoluble fibrin
Fibrin forms a mesh over the cut
Red blood cells & platelets are trapped by the mesh, and form a clot
Clot dried and becomes a scab
Outline the process of vaccination
Weakened pathogens or their antigens are injected into the body
The antigens stimulate an immune response by lymphocytes which produce antibodies
Memory cells are produced, this gives long-term immunity
Active immunity is gained
Vaccination helps control spread of diseases
Describe cholera as a disease
Cholera bacterium is transmissted in contaminated water
Cholera produces a toxin that causes secretion of chloride ions into the small intestines
This cause water potential of small intestines to lower
Water moves from nearby cells into the gut via osmosis
Faeces becomes watery
Causing diarrhoea, dehydration, loss of ions in the blood
Explain the link between physical activity and rate and depth of breathing
Physical activity use energy
Rate of respiration increases to provide energy
The increase of carbon dioxide concentration in the blood is detected by brain
Due to negative feedback, this leads to an increased rate and greater depth of breathing
Rate of gas exchange increased at alveoli
Excess carbon dioxide is removed, and more oxygen enters the blood
Outline how the oxygen debt is removed after exercise
During vigorous exercise, oxygen is used up and anaerobic respiration occurs
Lactic acid builds up in muscles and blood causing oxygen debt
After exercise, heart rate remains fast to transport lactic acid in the blood and muscles to the liver
Deeper and faster breathing continues on to supply oxygen for aerobic respiration of lactic acid in liver
Explain excretion in kidney
Blood is filtered in the glomerulus
Large molecules is filtered, while small molecules pass through and return to blood
Ultrafiltration removes water, glucose, urea, and ions into the Bowman’s capsule.
Reabsorption of all glucose, most water and some ions occurs in the nephron
Molecules are reabsorbed via active transport
Remaining substances form urine (contains urea, excess ions, and water).
Urine travels down the ureter to the bladder, then is excreted via the urethra.
Describe a simple reflex arc
Receptor detects a stimulus and generates an electrical impulse.
Sensory neurone carries the impulse from the receptor to the spinal cord
Relay neurone (in the spinal cord) transfers the impulse from the sensory neurone to the motor neurone
Motor neurone carries the impulse from the spinal cord to the effector (muscle or gland).
Effector carries out the response
Describe the events at a synapse
An impulse stimulates the release of neurotransmitter molecules from vesicles of pre-synaptic neurone into the synaptic gap
Neurotransmitter molecules diffuse across the gap
Neurotransmitter molecules bind with receptor protein on post-synaptic neurone
Recetor protein is complementary to the neurotransmitter molecules
An impulse is then stimulated in post-synaptic neurone
Explain accommodation to view near and distant objects
To view a near object,
Ciliary muscles contract.
Suspensory ligaments slacken.
Lens becomes thicker (more convex).
This increases the lens’s refractive power to focus light from a near object onto the retina.
To view a distant object,
Ciliary muscles relax.
Suspensory ligaments tighten.
Lens becomes thinner (less convex).
This reduces the refractive power to focus light from a distant object onto the retina.
Describe the control of blood glucose concentration by the liver and the roles of insulin
After meal, blood glucose becomes high
Glucose receptors (chemoreceptors) in islets of Langerhans in pancreas detect changes in blood glucose concentration
Pancreas secretes insulin
Insulin stimulates the liver and muscle cells take up glucose from blood
Insulin stimulates the liver and muscle cells to convert glucose into glycogen
This lowers the blood glucose concentration back to normal.
Describe the control of blood glucose concentration by the liver and the roles of glucagon
After fasting, blood glucose becomes low
Glucose receptors (chemoreceptors) in islets of Langerhans in pancreas detect changes in blood glucose concentration
Pancreas secretes glucagon.
Glucagon stimulates the liver to break down glycogen into glucose, and release glucose into the blood
This raises the blood glucose concentration back to normal
Describe the maintenance of a constant internal body temperature in mammals when hot
Human maintains stable body temperature through a process called thermoregulation
When body is too hot, hypothalamus in the brain detects temperature changes
Hypothalamus sends nerve impulses to effectors (sweat glands, muscles, blood vessels) to correct the change.
Sweat glands secrete sweat onto the skin.
Sweat evaporates, removing heat and cooling the body.
Muscles move as we move to seek shade, reducing activity and drinking fluids.
Vasodilation occurs
Describe the maintenance of a constant internal body temperature in mammals when cold
Human maintains stable body temperature through a process called thermoregulation
When body is too cold, hypothalamus in the brain detects temperature changes
Hypothalamus sends nerve impulses to effectors (sweat glands, muscles, blood vessels) to correct the change.
Muscles contract rapidly to increase respiration, which releases heat to warm the body.
Fatty tissue under the skin acts as an insulator, reducing heat loss.
Hair erector muscles contract, making the hair stand to provide further insulation.
Vasoconstriction occurs
Describe the maintenance of a constant body temperature in mammals' skin in hot weather
When the environment is too hot, thermoreceptor in the skin detects temperature changes
Receptor sends a nerve impulse through sensory to the hypothalamus
Hypothalamus sends nerve impulses to effectors (sweat glands, muscles, blood vessels) to correct the change.
Shunt vessels constrict, so more blood flows through skin surface capillaries.
Vasodilation occurs, the arterioles supplying skin capillaries widen,
More blood flows near the skin surface
More heat is loss by radiation to cool the body
Describe the maintenance of a constant body temperature in mammals' skin in cold weather
When the environment is too cold, thermoreceptor in the skin detects temperature change
Receptor sends a nerve impulse through sensory to the hypothalamus
Hypothalamus sends nerve impulses to effectors (sweat glands, muscles, blood vessels) to correct the change.
Shunt vessels dilate, so blood is diverted away from skin surface capillaries.
Vasoconstriction occurs, the arterioles supplying skin capillaries constrict
Less blood flow to the skin surface
This minimises heat loss, to conserve body temperature.
Explain the role of auxin in controlling shoot growth
Auxin is made in the shoot tip
Auxin diffuses through the plant from the tip
Auxin accumulates on the shaded side of the shoot.
This causes cells on the shaded side to elongate more, making the shoot bend towards the light.
Plant shoot shows positive phototropism
Auxin accumulates on the lower side of the horizontal shoot due to gravity.
More elongation occurs on the lower side, causing the shoot to bend upwards.
Plant shoot shows negative gravitropism
Explain the role of auxin in controlling root growth
Auxin is made in the shoot tip
Auxin diffuses through the plant from the shoot tip
Auxins collect on the lower side of the root due to gravity.
In roots, high auxin levels inhibit cell elongation, so the root bends downward.
Plant root shows positive gravitropism
Auxin moves to the shaded side, but in roots it inhibits cell elongation.
The cells on the brighter side grow more, so the root bends away from light.
Plant root shows negative phototropism
Describe the growth of the pollen tube and its entry into the ovule followed by fertilisation
After pollination, a pollen grain lands on the stigma.
It grows a pollen tube down through the style toward the ovary.
The pollen tube carries the male nucleus from the pollen grain.
The tube enters the ovule through a small opening called the micropyle.
The male nucleus fuses with the female nucleus (in the ovule); this is fertilisation.
A zygote is formed, which will develop into an embryo/seed
Explain how a protein is made
The gene that codes for the protein is found in the nucleus and does not leave it.
A messenger RNA (mRNA) molecule is made as a copy of the gene.
The mRNA is made in the nucleus, then moves into the cytoplasm.
In the cytoplasm, the mRNA passes through a ribosome.
The ribosome assembles amino acids into a protein molecule.
The sequence of amino acids in the protein is determined by the sequence of bases in the mRNA.
Explain how to use test cross to identify an unknown genoype
A test cross is used to determine whether an organism showing a dominant trait is homozygous dominant (e.g. TT) or heterozygous (e.g. Tt).
The organism with the unknown genotype is crossed with a homozygous recessive individual (e.g. tt).
If all offspring show the dominant trait, the unknown genotype is likely homozygous dominant (TT).
If some offspring show the recessive trait, the unknown genotype is heterozygous (Tt).
Describe natural selection
There is genetic variation within a population
The variation may be caused by mutation
Individuals within the population competes for resources
Individuals with advantageous features adapt better to the environment and survive
Survived individuals have more chance to reproduce
These individuals pass on their alleles to the next generation
Over time, this alleles become more common within population
Describe the development of strains of antibiotic resistant bacteria
Random mutations occur in the DNA of some bacteria, resulting in genetic variation, causing some bacteria are resistant to antibiotics.
Antibiotics (selection pressure) kill non-resistant bacteria, but resistant ones survive.
Resistant bacteria reproduce, passing on the resistance gene.
Over time, most of the population becomes resistant.
This is evolution by natural selection—the resistant trait becomes common.
New antibiotics are needed as resistant strains spread.
This process can repeat, leading to multi-drug resistant bacteria (e.g., MRSA).
Describe selective breeding
Humans select individuals with desirable features
Selected individuals are crossed (bred) together to produce the next generation.
Offspring showing the desirable features are selected and bred again.
Repeat the process over many generations.
Over generation, the desired allele becomes common
Explain the process of eutrophication
Excess fertiliser is washed into the waterway
This causes an increased availability of nitrate and other ions
Nitrate ions are needed for plant growth
Algae bloom occurs
Algae covers the surface of the water, blocking sunlight from underwater plants
Plants cannot photosynthesise to produce energy so they die.
The dead plants are broken down by decomposers
The increased aerobic respiration by decomposers used up the oxygen in the water
Dissolved oxygen in water is drastically reduced
This causes the death of organisms requiring dissolved oxygen in water
Outline the process of genetic modification
The DNA making up the desired human gene is isolated using restriction enzymes
This forms sticky ends on the cut out gene
A bacterial plasmid DNA is cut with the same restriction enzymes, forming complementary sticky ends
Human DNA is inserted into bacterial plasmid DNA using DNA ligase to form a recombinant plasmid
Recombinant plasmids are inserted back into bacteria
Bacteria containing recombinant plasmids multiply
The human gene in the bacteria is expessed to make human protein