Endocrinology - Hormone Mechanisms and Origins

Adenylyl Cyclase (cAMP)

Tropic hormones: CRH

Posterior pituitary: ADH (V2 receptor)

Anterior pituitary: TSH, ACTH, FSH, LH

HCG, PTH, Calcitonin, MSH, Glucagon, beta 1/2 adrenergic receptors

Phospholipase C (PLC)

Tropic hormones: GnRH, GHRH, TRH

Posterior pituitary: OT, ADH (V1 receptor)

Angiotensin II, alpha 1 adrenergic receptors

Steroid hormone mechanism

Sex hormones: Testosterone, estrogen, progesterone

Adrenal hormones: Aldosterone, glucocorticoids

Thyroid hormones (T3/T4), vitamin D

Tyrosine kinase (TK)

Anterior pituitary: hGH, PRL

IGF-1 (made by liver after hGH release), insulin

Guanylate cyclase mechanism (cGMP)

Atrial natriuretic peptide (ANP)

Nitric oxide (NO)

Synthetic location of ADH

Son, go to the bathroom

Supraoptic nucleus (SON) of HT

Synthetic location of oxytocin

Think 3rd ventricle, like the substantia nigra

Paraventricular nucleus (PVN) of HT

Synthetic location of somatostatin (GHIH, GIH, SRIH)

Anti-release! Arc away

Anterior periventricular nucleus (APN) and arcuate nucleus (AN) of HT

Synthetic location of dopamine (PIH)

Arc to Perry St.

Arcuate nucleus (AN) and periventricular nucleus of HT

Synthetic location of growth hormone releasing hormone (GHRH)

Are you growing?

Arcuate nucleus (AN) of HT

Synthetic location of corticotropin releasing hormone (CRH)

CPR - corticotropin _(nucleus)_ release!

Paraventricular nucleus (PVN) of HT

Synthetic location of thryotropin releasing hormone (TRH)

They’re Paralympians!

Paraventricular nucleus (PVN) of HT

Synthetic location of prolactin releasing hormone (PRH)

P&P

Paraventricular nucleus (PVN) of HT

Synthetic location of gonadotropin releasing hormone (GnRH)

Preoptic nucleus (PON) of HT

Synthetic location of human growth hormone (hGH)

Somatotrophs of anterior pituitary

Synthetic location of adrenocorticotropic hormone (ACTH)

Corticotrophs of anterior pituitary

(NOTE - TROPIC HORMONE)

Synthetic location of thryoid stimulating hormone (TSH, thyrotropin)

Thyrotrophs of anterior pituitary

(NOTE - TROPIC HORMONE)

Synthetic location of prolactin (PRL)

Lactotrophs of anterior pituitary

Synthetic location of follicle stimulating hormone (FSH) and luteinizing hormone (LH)

Gonadotrophs of anterior pituitary

NOTE - TROPIC HORMONES