bloodbank day 7

what is the most important reason for crossmatching infants

HDFN

Can be due to incompatibility, such as an O mom and A baby

what causes more severe HDFN in infants, ABO or Rh incompatibility

Rh incompatibilty

how can a mom and baby ABO incompatibility prevent Rh incompatibility

Baby (ex A cells) cells will be cleared by moms anti-baby ( ex O mom makes Anti-A) before it gets the chance to become sensitized to babies potential Rh positive cells and make the antibody

two most important things for selecting a unit to transfuse in an infant

age of unit

choosing a blood type

why is age of a unit important when choosing what units to crossmatch for an infant

-long storage time is bad

-ATP decreases, making RBC less viable

-2,3DPG decreases which causes increased affinity of oxygen to hemoglobin, allowing less oxygen to go to the tissues

-older blood may have micro clots and fibrin strands

why is choosing the correct blood type unit for an infants crossmatch so important

-cant give baby blood that has an antigen the mother has an antibody to

-if baby or mom is O, give baby O

-crossmatch blood ur giving baby with MOMs plasma to see if she has antibodies

elution

procedure to split bound antibody from RBCs to identify them

Sda

Sid blood group

is an inherited polygagglutinin that is found in the urine and saliva of Sd+ people

how are antibodies identified in the lab

by their reaction pattern with an antibody ID panel