Lab Animal Technical Skills

What is the purpose of GLPs?

Govern the technical conduct of research from start to finish.

GLPs regulate which of the following types of research?

Safety testing of various products for human and animal use including drugs

Which individual represents the single point of study control at the research facility?

study director

What do you call a chronological list of action steps written for completion of a task?

SOPs

Which of the following in NOT an example of raw data?

Copied temperatures from printouts into a notebook

Which of the following DOES NOT result in a facility getting disqualified?

Quality Assurance inspections had to be performed during a study.

T or F: Quality Assurance reports directly to the Study Director and must also be engaged in research.

False

T or F: Standard SOPs are written out step-by-step within each study protocol.

False

T or F: Only the most current SOPs must be kept for record inspection; previous drafts are discarded.

False

T or F: Personnel must be trained to perform each SOP; SOPs are not training manuals!

True

For which two species does the Animal Welfare Regulations require a documented environmental enrichment/exercise plan?

Dogs and nonhuman primates

Which environmental enrichment type would NOT be provided if mice on a study receive a special diet?

Food treats scattered in the bedding

Which item is NOT an appropriate form of enrichment for mice?

puzzle feeders

According to the AWA and Animal Welfare Regulations, when can an IACUC exempt specific animals from environmental enrichment programs?

when doing so is scientifically justified

When adding enrichment for guinea pigs, it is important to remember that:

they scare easily

What is an appropriate goal for an enrichment program?

increase species-typical behaviors

Which of the following is NOT a reason for witholding pre-anesthetic drugs in rats and mice?

Calculating doses would be inconvenient and waste drug based on rodent size.

Which route is most commonly used for administration of injectable anesthesia in rodents?

IP

Which agent is the most commonly used for inhalant anesthesia in rodents?

Isoflurane

Why is thermal support and monitoring so important during rodent anesthesia?

Rodents have a large surface area over which heat is lost rapidly.

Fluid support for rodents under anesthesia is provided via which of the following methods?

SC/SQ

How should you house rodents recovering from anesthesia?

Individually in a cage.

Hypothermia is used for anesthesia in rodent pups if all but which condition is met?

Pups are unconscious.

Which of the following species are coprophagic?

Rabbits

Why should rabbits be sedated prior to using inhalant anesthesia with a face mask?

Rabbits will become stressed and struggle without prior sedation

Which anatomical feature contributes to the challenge of intubation in rabbits?

Large incisors

Other than using drugs, which non-pharmaceutical techniques can you use to manage pain?

All of these

What is a grimace scale?

Utilizes facial features and expressions to assess pain

A '2' on a grimace scale for any feature or expression means that:

Pain is severe

Is this rat in pain?

Yes

Identify this piece of equipment.

Induction chamber

T or F: Atropine is the preferred anticholinergic for use in rabbits.

False

T or F: Pain scales work well even if you are not familiar with that species' behaviors.

False