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Malignant Potential
Benign: No metastasis
Resembles tissue of origin
Malignant: Metastasis potential
Poor differentiation
Rapid growth + infiltration
Tissue of Origin: Epithelium
Benign: -oma
Malignant: Carcinoma
Ex:
Adenocarcinoma: Glandular
Squamous cell carcinoma
Tissue of Origin: Connective Tissue
Benign: -oma
Malignant: Sarcoma
Ex:
Osteosarcoma
Liposarcoma
Tissue of Origin: Melanocytes
Benign: Nevus
Malignant: Melanoma
Tissue of Origin: Hematopoietic Tissue
Malignant: Leukemia
Tissue of Origin: Lymphoid Tissue
Malignant: Lymphoma
Tissue of Origin: Germ Cells
Benign: Mature teratoma
Malignant: Immature teratoma
Cancer Staging: Types
Clinical + Radiological
Pathological
Clinical + Radiological Staging
cTNM
Staging based on info during diagnosis
History + physical
Imaging
Biopsies
Pathological Staging
pTNM
Supplement/modify staging based on histopathological exam
More accurate
Refine prognosis
Guide treatment