1- 15 General Pharmacology, Anti-inflammatory, Anti-infectives

Paracetamol D

Non-opioid Analgesic / Antipyretic

Paracetamol R

Fever and Mild to Moderate Pain

Paracetamol U

Hepatotoxicity

Paracetamol G

Monitor total daily dose; assess liver disease history

Paracetamol M

Maximum adult dose is generally 4 g/day; consider lower limits in liver disease or chronic alcohol use.

Ibuprofen D

Nonsteroidal Anti inflammatory Drug (NSAID)

Ibuprofen R

Pain and Inflammation

Ibuprofen U

Gastrointestinal Bleeding

Ibuprofen G

Administer with food; monitor for GI bleeding

Ibuprofen M

Avoid prolonged use in patients with peptic ulcer disease.

Diclofenac D

NSAID

Diclofenac R

Musculoskeletal Pain and Inflammation

Diclofenac U

Gastrointestinal Bleeding

Diclofenac G

Monitor for abdominal pain or bleeding

Diclofenac M

Use the lowest effective dose for the shortest duration.

Celecoxib D

Selective COX-2 Inhibitor

Celecoxib R

Osteoarthritis and Rheumatoid Arthritis

Celecoxib U

Cardiovascular Thrombotic Events

Celecoxib G

Assess cardiovascular history

Celecoxib M

Lower GI toxicity than traditional NSAIDs but not risk-free.

Ketorolac D

NSAID

Ketorolac R

Short-term Moderate to Severe Pain

Ketorolac U

Gastrointestinal Bleeding

Ketorolac G

Limit therapy to 5 days or less

Ketorolac M

Do not use for chronic pain because of increased toxicity.