Bio 150 Test Unit 2.7: Cell-Cell-Communication II

Fill in the blank:

Insulin is released into the blood due to ___ blood glucose.

High

What is the insulin receptor called?

Receptor tyrosine kinase

True or False:

Receptor tyrosine kinases phosphorylate their own tyrosines.

True

True or False:

Phosphorylated tyrosines on RTKs are binding sites for target proteins.

True

What is the order of these processes?

(1) Autophosphorylation is activated on RTK tyrosines.

(2) Insulin binds to receptor.

(3) Target proteins bind to phosphorylated tyrosines.

(4) Receptor dimerizes (changes is confirmation).

2, 4, 1, 3

Where is glucose stored in the human body?

Liver

Muscles

What does the binding of the G-protein to the RTK trigger?

A kinase cascade

What is the insulin kinase cascade?

MAP3K→MAP2K→MAPK→Enzymes/Motors/Gene Regulatory Proteins

What does insulin being a “mitogen” mean?

It signals the cell to divide.

What are gene regulatory proteins activated by?

Phosphorylation

True/False:

Any cell can respond to a molecular signal.

False. They need the correct receptor protein.

True/False:

Gene regulatory proteins help RNA Polymerase bind to DNA.

True