Post-Polio Syndrome (PPS)

What is post-polio syndrome (PPS)?

• Late motor neuron pathology after previous poliomyelitis

• Affects anterior horn cells

• Surviving axons initially compensate by increasing their innervation ratio

• Eventually compensatory reinnervation fails

• Results in ongoing muscle denervation

When does post-polio syndrome typically develop?

• Occurs decades after recovery from initial polio infection

• Average interval: ~25 years

• Develops in approximately 25–50% of individuals with previous polio

What are the common signs and symptoms of post-polio syndrome?

• Slow, progressive weakness

• Fatigue

• Muscle atrophy

• Pain

• Swallowing difficulties

What is the treatment for post-polio syndrome?

• No pharmacological treatment alters disease progression

• Treatment focuses on:

  • Lifestyle modification

  • Symptom management

  • Supervised exercise

  • Functional independence

  • Adaptive equipment

  • Patient education

• Goal → maintain as much independence as possible

What is the key PT principle when treating post-polio syndrome?

• Emphasize supervised exercise without overworking weakened muscles

• Promote energy conservation/lifestyle modification

• Maintain functional independence

• Use adaptive equipment as needed

• Focus on function and symptom management, not reversing the disease process