chapter 5 - hematopoiesis

hematopoiesis

process of formation and development of blood cells

liver

primary site of blood cell production during the second trimester of fetal development

thymus

organ responsible for the maturation of T lymphocytes and regulation of their expression of CD4 and CD8

iliac crest

best source of active bone marrow from a 20-year old

angiogenesis

physiologic programmed cell death

spleen

organ that is the site of sequestration of platelets

condensation of nuclear chromatin

morphologic changes that occurs during normal blood cell maturation

T lymphocyte

cell that is a product of the common lymphoid progenitor

EPO

growth factor that is produced in the kidneys

used to treat anemia associated with kidney disease

FLT3 ligand

cytokine that is required very early in the differentiation of a hematopoietic stem cell

extramedullary hematopoiesis in the liver and spleen

px has severe anemia, bone marrow is unable to effectively produce RBCs to meet the increased demand

what is the body’s response

have the ability of self-renewal by asymmetric division

hematopoietic stem cells produce all lineages of blood cells in sufficient quantities over the lifetime of an individual because they?