Substances of Endothelial Cells

Prostacyclin (PGI2)

inhibits platelet aggregation

Nitric oxide

prevents platelet activation

Nitric oxide

induces smooth muscle relaxation

TFPI (Tissue factor pathway inhibitor)

controls activation of the extrinsic pathway

CD 39

degrades ADP

Thrombomodulin

inhibits thrombin formation

Thrombomodulin

activates protein C

Heparan sulfate

co-factor of anti-thrombin/anti thrombin III

13-HODE

inhibits platelet adhesion

vWF

(key) important in platelet adhesion

P-selectin (CD-62)

adhesion molecule

P-selectin (CD-62)

promotes platelet and leukocyte binding

PECAM’s

promotes platelet and leukocyte binding

TPA

activates fibrinolysis by converting plasminogen to plasmin

PAI-1

inhibits plasmin generation and fibrinolysis

TAFI

activated by thrombin that binds to thrombodulin