ABPs and MAPs

cell bio block 3

lactrunculin

actin drug

depolymerizes

cytochalisn B

actin drug

depolymerizes

phalloidin

actin drug

stabilizes

thymosin B4

sequesters actin monomers, prevents growth

profilin

actin

promotes polymerization after nucleation

cofilin

actin

severs filaments, promotes polymerization of new filaments

formins

actin

nucleator generating long unbranched filaments + end

tandem actin monomer binding proteins

nucleator, long unbranched filaments - end

arp 2/3

actin

activated by wasp to form branched filaments from middle of existing filaments

gelsolin

actin

severs, caps + end of fragments, leads to depolymerization

cap 2

actin

caps filaments, stabilizes

trypomyosin

actin

stabilizes

fimbrin

actin

cross links filaments tightly

alpha actinin

actin

cross links filaments wider apart

filamin

actin

makes mesh work of filaments

spectrin

actin

link filaments to membrane, binds to ankyrin

ERM

actin

link filaments to membrane

dystrophin

actin

links filaments to muscle cell membrane

taxol

MT drug

stabilizes

colchicine

MT drug

depolymerization

nocodazole

MT drug

depolymerization

gamma turc

MT

nucleation, promotes growth

+ TIPS

MT

link to membrane by interacting with + end GTP cap

stathmin

MT

leads to catastrophe, prevents growth

kinesin 13

MT

depolymerization at ends

MAPs

MT

stabilizes

Tau

MT neurons

cross links tightly

MAP-2

MT neurons

cross likes wider apart

Plectin

MT

cross links to IFs