Oncology Class Quiz Questions (copy)

What genes are responsible for "stopping" tumor cell growth?

Tumor Suppressor Genes

What likely caused these lesions?

Papilloma virus

What causes squamous cell carcinoma on the face of light face coloured animals?

Ultraviolet radiation

7yo NM Boxer presented with 2cm mass of the left lateral thigh.

• What’s your diagnosis for this patient?

• Where would you check for metastasis with this tumor type?

• Round cell, mast cell tumor

• Check Lymph nodes for metastasis

6yo SF Great Dane presented for lameness. Exam localizes lameness of left forelimb, specifically the shoulder.

• What do you want to do?

• What’s your differential?

• Radiograph the shoulder and thorax

• Top differential is a Sarcoma

What is the primary goal of chemotherapy in cancer management?

Maximize survival while maintain a good quality of life

Which of the following statements about chemotherapy is true?

• Chemotherapy is a primary treatment for all cancer types.

• Chemotherapy primarily targets rapidly dividing cells.

• Chemotherapy is only effective during the acute phase of cancer.

• All chemotherapy agents are equally effected regardless of tumor type.

Chemotherapy primarily targets rapidly dividing cells.

When do most patients develop gastrointestinal symptoms after chemotherapy has been administered?

3-5 days

When do patients develop bone marrow suppression with most of the commonly used chemotherapies?

7-10 days

What is the primary goal of metronomic chemotherapy?

To slow down tumor progression and metastasis

Which drug causes severe kidney toxicity?

Cisplatin

Which drug is the most severe tissue vesicant?

Doxorubicin

Which drug is an enzyme that is only effective against lymphoma and leukemia?

L-asparaginase

True/False: Three view thoracic radiographs are required for staging of lymphoma in dogs as the disease is often found in the lungs

False

Two view thoracic radiographs are required for staging of lymphoma in dogs as the disease is often found in the Lymph nodes

Using prednisone alone to treat lymphoma will…

reduce remission rates to chemotherapy protocols by 50%

Which of the following factors is NOT considered a prognostic variable for dogs diagnosed with lymphoma?

• Age of the dog

• Hypercalcemia

• Treatment response

• Immunophenotyped

Age of the dog

Which of these lymphoma etiologies is found in cats but NOT dogs?

• Genetic factors

• Herbicide exposure

• Living in an industrial area

• Retroviral infection

Retroviral infection

What risk factor is associated with an increased likelihood of developing feline lymphoma?

Exposure to environmental tobacco smoke

Which form/forms of lymphoma in cats have the best prognosis?

Small Cell GIT and Nasal

True/False: Cats with renal lymphoma have an overall good prognosis.

False: Cats with renal lymphoma have an overall poor prognosis.

True/False: In cats, the multicentric/generalized lymphadenopathy form of lymphoma is the most commonly diagnosed form?

False: In cats, the multicentric/generalized lymphadenopathy form of lymphoma is rare?

Chlorambucil and prednisone would be most effective at treating this type of lymphoma in a cat?

Small cell GIT lymphoma

Which cells do NOT come from the myeloid line?

• monocytes

• platelets

• lymphocytes

• eosinophil

lymphocytes

What diagnostic will provide the most information on a suspected case of leukemia?

Flow cytometry

What drug is used to block H1 receptors?

diphenhydramine

Which of these is the new intertumoral injection used to treat mast cell tumors?

Steifonta

What key feature of mast cell tumors in dogs can affect prognosis?

Tumor grade

Which is NOT a potential squeal of mast cell tumor derogation?

• GIT ulceration

• Delayed wound healing

• Increased heart rate

• Bone pain

Bone pain

Most commonly used medication used to manage symptoms associated with mast cell tumors in cats?

Antihistamines and steroids

Which statement about soft tissue sarcomas is FALSE?

• They are locally invasive

• They have well defined margins

• They can be confused with lipomas on palpation

• Rarely metastasize to the lymph nodes

False: They have well defined margins

• they do not have well defined margins

What is the most common site of metastasis for soft tissue sarcomas?

Lungs

Overall, approximately what percentage of feline injection site sarcoma metastasize?

25%

Which of the following is TRUE regarding the grading of feline injection site sarcomas?

• Most are low grade

• Most are high grade

• Grade does not correlate with prognosis

• Grading is not possible for these tumors

Most are high grade

What type of hemangiosarcoma generally has a better prognosis?

Dermal or cutaneous

Which diagnostic test is recommended to rule out or in right atrial hemangiosarcoma?

Echocardiogram

Which breed has a higher incidence of concurrent right atrial and splenic involvement in hemangiosarcoma’s?

Golden Retriever

Small breed dogs more common develop osteosarcoma where?

Axial skeleton

True/False: Aspiration of a suspected osteosarcoma lesion is often easy and quick.

True: Aspiration of a suspected osteosarcoma lesion is often easy and quick.

True/False: Dogs do not handle limb amputation well and limb sparing surgery is recommended for dogs with OSA.

False: Dogs do handle limb amputation well and limb sparing surgery is not recommended for dogs with OSA.

The addition of chemotherapy to a dog that has undergone amputation for OSA has a median survival time of?

12 months

What is the most common location for tumors of the GI tract in both dogs and cats?

Oral cavity

Which of the following oral tumors in dogs has an overall good prognosis post complete surgical resection?

Acanthomato’s equlis

Which oral tumor in dogs is known for being the most aggressive and has a high rate of metastasis?

Melanoma

What is the main treatment for perianal adenomas in dogs?

Castration

Which treatment approach offers the best long-term prognosis for AGASACA?

Complete surgical excision when possible

True/False: Mammary tumors in dogs are predominantly malignant with high rates of metastasis.

False: Mammary tumors in dogs are half and half benign or malignant with 50% rates of metastasis.

True/False: radical bilateral chain mastectomy's should be recommended for all dogs with mammary tumors.

False: radical bilateral chain mastectomy's should not be recommended for all dogs with mammary tumors.

True/False: Cats with mammary tumors have a worse prognosis than dogs with mammary tumors

True: Cats with mammary tumors have a worse prognosis than dogs with mammary tumors

True/False: radical bilateral chain mastectomy's should be recommended for most cats with mammary tumors.

True: radical bilateral chain mastectomy's should be recommended for most cats with mammary tumors.

True/False: The BRAF assay is the current diagnostic of choice for dogs with suspected TCC.

True: The BRAF assay is the current diagnostic of choice for dogs with suspected TCC.