ABC (ATP-Binding Cassette) Transporters

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6 Terms

1
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What is the main function of ABC transporters?

To move a wide variety of substrates using ATP hydrolysis.

2
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What kinds of molecules do ABC transporters move?

Toxins, drugs, phospholipids, peptides, and proteins.

3
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What is MDR1 (ABCB1) and what does it do?

A drug transporter that exports lipophilic drugs; associated with multidrug resistance in cancer cells.

4
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What is CFTR and what is its role?

An ABC transporter that moves Cl⁻ ions; defective CFTR causes cystic fibrosis.

5
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What disease is caused by mutations in ABCA1?

Tangier’s disease, due to defective cholesterol export.

6
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What disease is linked to ABCD1 mutations?

Adrenoleukodystrophy, caused by failure to transport very long chain fatty acids.