[PART 3] [GONAD] Clinical Chemistry [RODRIGUEZ]

testosterone

Testes secretes what hormone

germ cells (spermatogonia) & Sertoli cells (nurse cell)

Seminiferous tubule Contains?

T>D>E>V

Tubuli recti> Ductuli efferentes testes> Epididymis> Vas deferens

the sperm moves through:

Interstitium

Contains Leydig cells

Leydig cells

synthesize testosterone

FSH

Acts on germ cells

- Spermatogenesis

LH

Acts on Leydig cells

-Testosterone synthesis

Testosterone

Principal androgen hormone

2-3%

How many % of Free Testosterone

45%

How many % of Testosterone are SHBG bound

50%

How many % of Testosterone are albumin bound

8 AM

Testosterone Highest level at ____?

8 PM

Testosterone lowest level at ____?

5 alpha reductase

converts testosterone to DHT

Testosterone

promotes differentiation of male genital tract

mullerian regression factor

Sertoli Cell produce____________ _______________ __________that aids in regression of female primordial genital tract

Klinefelter's syndrome

Small testicles, gynecomastia, azoospermia (sterile)

gynecomastia

Male boobs

Testicular feminization syndrome

Lack of testosterone action what syndrome?

Myotonic Dystrophy

testicular failure (in the 4th decade of life)

5α-Reductase Deficiency

Female phenotype until puberty

Sertoli Cell-Only Syndrome

What Syndrome Lacks germ cells

Kallmann's Syndrome

X-Linked recessive

- Hypogonadism during puberty

Anosmia (inability to smell)

midline defects (cleft palate)

Kallmann's Syndrome associated disorder?

30

testosterone is decreased after age__________________?

110 ng/dL

Average decline of testosteron per decade

2-4 million

The Ovaries Contains ___________________ primordial follicles

cumulus cells

The maturing ovum attaches inside via?

Corpus luteum

The Graafian follicle becomes

corpus luteum

produces progesterone & estrogen

Estradiol

Principal estrogen is?

Estrone and Estriol

Primary metabolites of Estradiol

Progesterone

Promotes thickening of the cervical mucus

Progesterone

Marker of ovulation and dominant hormone in luteal phase

failure of implantation of embryo

Progesterone Deficiency results in?

hirsutism

Excess hair growth

Masculinization or virilization

Loss of female characteristics

Inhibin

Inhibit FSH production

Activin

Enhances FSH secretion & induces steroidogenesis

Estrogen

It Increases thickness of the endometrium

Thelarche

Development of breast

Menarche

Initiation of menses

Amenorrhea

Absence of menses

Oligomenorrhea

Irregular menstrual bleeding w/ cycle lengths >35-40 days

Menorrhagia

Uterine bleeding >7 days

Polycystic Ovary Syndrome

Infertility, chronic anovulation, hirsutism, glucose intolerance, hyperlipidimia and hypertension

Hirsutism

Abnormal androgen sensitive terminal hair growth