Nitric Oxides

Who conducted experiment which led to the discovery of NO

Furchgott

What amino acid is used to produce NO

arginine

What enzyme is used in the production of NO

• NOS

• nitric oxide synthase 

What are the three types of NO’s 

• nNOS(neuronal)

• iNOS(inducible)

• eNOS(endothelial)

what does NO activate

• guanylate cyclase

what is the downstream effect and its inhibitor

• soluble guanylate cyclase 

• inhibitor methylene blue 

What does the activation of guanylate cyclase

• production of cGMP 

• causes activation of protein kinases 

• degraded by PDE

Nitric Oxide effects

• Vascular 

• septic shock 

• inflammation 

• respiratory disorders 

• Nervous system 

What does NO cause in smooth muscles

relaxation

what time of signalling does Nirtic oxide use

• retrograde signalling 

where are NO molecules generated

• endogenously 

What time of juice has a lot of NO3

• beetroot juice 

How is No3 conveted to NO2 and NO in body

• saliva converts No3 to NO2

• gastric acid and enzymes convert NO2 to NO