BB Complement Alternative Pathway

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Last updated 2:04 AM on 9/22/26
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14 Terms

1
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What is the TRIGGER of the Alternative pathway?

LPS/Microbe surface

2
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What binds first to the microbial surface in the Alternative Pathway?

C3w

3
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What binds to C3w after it binds to the microbe surface?

Factor B

4
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What happens to Factor B after it binds to C3w?

FACTOR D cleaves it into Ba and Bb

5
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What cleaves Factor B?

Factor D

6
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What does Factor D cleave Factor B into?

Ba & Bb

7
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Where does Bb bind?

C3w

8
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What forms the C3 convertase in the Alternative Pathway?

C3wBb

9
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What STABILIZES in the Alternative Pathway?

Properdin

10
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What does C3wBb do?

Cleave C3 to C3a & C3b

11
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What is C3a best at?

INFLAMMATION

12
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What is C3b best at?

OPSONIZATION

13
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What forms the C5 convertase in the Alternative Pathway?

C3wBbC3b

14
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How does the Alternative pathway end?

C5 being cleaved

C5b binding and facilitating the MAC complex

LYSIS