NAUSEA/VOMITING AGENTS

Ondansetron

Zofran, Zuplenz — 5-HT3 receptor antagonist

Ondansetron PO/Function/Common Use

PO, IV — Blocks serotonin-3 receptor — Nausea, vomiting

Ondansetron Adverse Drug Reactions/Special Considerations

Irregular heartbeat (QTc prolongation) — Nausea, diarrhea, constipation, headache — No special considerations

Metoclopramide

Reglan — Dopamine antagonist

Metoclopramide PO/Function/Common Use

PO, IV — Blocks dopamine receptor — Nausea, vomiting

Metoclopramide Adverse Drug Reactions/Special Considerations

Irregular heartbeat (QTc prolongation), movement disorder — Fatigue/drowsiness, restlessness, fluid retention — No special considerations

Prochlorperazine

Compazine, Compro — Antipsychotic and antiemetic

Prochlorperazine PO/Function/Common Use

PO, IV — Blocks dopamine receptor — Nausea, vomiting

Prochlorperazine Adverse Drug Reactions/Special Considerations

Irregular heartbeat (QTc prolongation), movement disorder — Fatigue/drowsiness, restlessness, fluid retention — No special considerations

Promethazine

Phenergan, Promethegan, Phenadoz — H1 antagonist

Promethazine PO/Function/Common Use

PO, IV — Blocks dopamine AND histamine-1 receptors — Nausea, vomiting

Promethazine Adverse Drug Reactions/Special Considerations

Irregular heartbeat (QTc prolongation), movement disorder — Fatigue/drowsiness, restlessness, fluid retention — No special considerations