Citric Acid Cycle

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10 Terms

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Cataplerotic reactions

Deplete the components of the cycle

  • Products are consumed in other pathways

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Anaplerotic reactions

Replenish the components of the cycle

  • Products from other pathways are converted to substrates of the cycle

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Step 1:

Oxaloacetate → Citrate

This is a very exergonic reaction due to the hydrolysis of the acetyl-CoA thioester

<p>This is a very exergonic reaction due to the hydrolysis of the acetyl-CoA thioester</p>
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Step 2:

Citrate → Isocitrate

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Step 3:

Isocitrate → α-Ketoglutarate

<p></p>
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Step 4:

a-ketoglutarate → succinyl-CoA

Enzyme: α-Ketoglutarate dehydrogenase

<p>Enzyme: α-Ketoglutarate dehydrogenase </p>
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Step 5:

Succinyl-CoA → Succinate

This is the only substrate-level phosphorylation reaction of the cycle

(right to left in pic)

<p>This is the <strong>only </strong>substrate-level phosphorylation reaction of the cycle</p><p>(right to left in pic)</p>
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Step 6:

Succinate → Fumarate

(right to left in pic)

<p>(right to left in pic)</p>
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Step 7:

Fumarate → Malate

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Step 8:

Malate → Oxaloacetate

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