Cystic Fibrosis Overview - ACUTE Pulmonary (APE) Treatments

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6 Terms

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  • Episode of acute worsening of pulmonary symptoms

  • Cumulative effects of intermittent episodes of APE - cause progressive decline in lung function over time

Definition of Acute Pulmonary Exacerbations

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  • fatigue, weight loss/decreased appetite, increased respiratory symptoms (cough, sputum, SOB)

Clinical presentation of APE

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  • Respiratory cultures

  • PFT’s (>10% decline expected)

How do we test for APE/Diagnose APE?

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  • Continue chronic therapies !!!!!! 

  • Intensify ACT (increase to 3-4x daily)

  • Optimize nutrition

  • Systemic ABX

How do we TREAT APE?

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Mild to moderate exacerbation? - Outpatient

Where would we give oral ABX to a patient having APE exacerbation?

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Moderate to severe? - Inpatient

Where would we give systemic ABX to patient having APE Exacerbation?