Common Drug Interactions & Contraindications

Warfarin

Drug Interactions: NSAIDs, Antibiotics, Fish Oil, Coenzyme 10, Garlic Supplements, Ginko Biloba, Vitamin K

Side Effects: Excessive bruising / bleeding

Pregnancy Category: X

NSAIDs

Drug Interactions: When taken with Lithium or Methotrexate, can cause toxicity

Interactions: Increased Risk of Bleeding with Coumadin (warfarin)

HMG-CoA Reductase Inhibitors (-statins)

Food Interaction: Grapefruit inhibits metabolism leading to muscle damage

Pregnancy Category: X

Benzodiazepines & Hydrocodone

Drug Interaction: Benzodiazepines and Hydrocodone, taken together, can cause respiratory depression

Pregnancy Category: D (Benzodiazepine)

Clopidogrel and PPIs

Drug Interaction: Clopidogrel and PPIs, when taken together can reduce effectiveness of Clopidogrel

Antibiotics

Drug Interaction: Increased risk of bleeding with Anticoagulants, reduce effectiveness of birth control

Pregnancy Category: varies, Doxycycline is Category D

Ace Inhibitor (ACEi)

Pregnancy Category: D

Serotonin Syndrome

Drug Interaction: SSRIs or SNRIs and MAOIs, taken together, can cause Serotonin syndrome

Digoxin & Diuretics

Drug Interaction: Digoxin and Diuretics, taken together, can cause increased risk of Digoxin toxicity

Lithium

Drug Interactions: Alcohol, NSAIDs, and Methotrexate should be avoided when taking Lithium

Pregnancy Category: D