CPTC Review - Hospital Development/Process Support

Flashcards covering terms and definitions related to hospital development and process support in organ donation and transplantation.

Uniform Anatomical Gift Act (UAGA)

Legislation passed to improve the system for organ, tissue, and eye donation; created the modern registry and first-person authorization.

First Person Authorization (FPA)

The donor has legally authorized donation upon declaration of death.

End Stage Renal Disease Act (1972)

Provides payment for dialysis, making kidney transplants less expensive than long-term dialysis.

Uniform Determination of Death Act (UDDA 1981, 1985)

Provides a medically sound and legal basis for determining brain death.

National Organ Transplant Act 1984

Provided federal grants to establish OPOs, called for a national network to coordinate organ allocation, and outlawed the sale of organs.

Organ Procurement and Transplantation Network (OPTN)

Maintains organ transplant waitlist and organ placement process, develops policies regarding allocation, recovery, and transportation.

Scientific Registry of Transplant Recipients (SRTR)

Evaluates the clinical status of solid organ transplantation and maintains a national database of transplantation statistics.

Donor Bill of Rights (1994)

Ensures families receive information, have time alone with the donor, understand brain death, and have the right to bereavement follow-up support.

Hope Act (2013, 2015)

Called for the development and publication of research criteria relating to transplantation of HIV-positive organs into HIV-positive individuals.

Centers for Medicare & Medicaid Services (CMS)

Issues Conditions of Participation (CoP) for organ procurement to increase donation.

Dead Donor Rule

An informal rule stating that donors must be declared dead prior to donation.

CMS Donor Definition

A deceased individual from whom at least one vascularized organ is transplanted.

CPRA (calculated panel reactive antibody)

estimates the percentage of donors with whom a particular recipient would be incompatible

Physiological response to Brain Death

The massive vasodilation from systemic inflammation and catecholamine storm, loss of pituitary function, and inability to regulate temperature.

A1 receptors

Receptors on arteries; stimulate arteries and increase BP by vasoconstriction.

Antibody (aka immunoglobulin)

The protective protein produced by the immune system in response to a foreign substance (antigen).

HLA tissue typing: Human Leukocyte Antigen

Genetic matching between donors and recipients using 6 antigens in the blood to create a genetic profile.

Calculated Panel Reactive Antibody (CPRA)

estimates the percentage of donors with whom a particular recipient would be incompatible

Warm Ischemic Time

The total time between cessation of blood flow through the organ and the establishment of effective hypothermic temperature.

Purpose of Preservation

Induce hypothermia to decrease O2 requirements, reduce cell swelling, maintain intracellular energetics, prevent electrolyte imbalance and intracellular acidosis.