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What are the types of chronic pattern of reactive lymphadenitis?
Follicular hyperplasia, paracortical hyperplasia, sinus histiocytosis
What are the 2 main types of lymphomas?
Hodgkin lymphoma, non-Hodgkin lymphoma
Characteristics of Hodgkin Lymphoma
1) more often localized to a single axial group of nodes
2) orderly spread by contiguity
3) mesenteric nodes and Waldeyer ring are rarely involved
4) extranodal presentation is rare
Characteristics of non-Hodgkin lymphomas
1) more frequently involvement of multiple peripheral nodes
2) noncontiguous spread
3) Waldeyer ring and mesenteric nodes are commonly involved
4) extranodal presentation is common
Classification of Hodgkin lymphomas:
Classic Hodgkin lymphoma and non classic Hodgkin lymphoma
What cell is characteristic for Hodgkin lymphomas?
Reed-Sternberg cells
What are the types of non Hodgkin lymphomas?
Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL)
In what age are non Hodgkin lymphomas presented?
Patients older than 50 years (median 60 yoa)
What is Richter syndrome
Transformation of CLL to diffuse large B-cell lymphoma
What is the most common chromosomal translocation associated with follicular lymphoma?
chromosomal translocation involving BCL2
What are the risk factors for developing MALT?
1) chronic infections (Helicobacter Pylori)
2) autoimmune disease (Sjögren syndrome, Hashimoto thyroditis)
Localization of MALT:
stomach, salivary gland, thyroid (remains localized at the site of origin for a long time, spreading systemically only late in its course)
What can MALT transform into?
Diffuse large B-cell lymphoma
Translocation of which genes may lead to diffuse large B-cell lymphoma?
BCL6, BCL2, MYC
Amplification of which gene in DLBCL has the worst outcome?
MYC amplification
Mycosis fungoides are derived from what cells?
T cells (T-cell lymphoma)
What is the most common variant of mycosis fungoides?
Sezary syndrome
Define sezary syndrome
1) generalized erythrodermia
2) generalized lymphadenopathy
3) presence of neoplastic T cells in the skin, lymph nodes and peripheral blood