Lymphoid (morhp midterm 2)

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18 Terms

1
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What are the types of chronic pattern of reactive lymphadenitis?

Follicular hyperplasia, paracortical hyperplasia, sinus histiocytosis

2
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What are the 2 main types of lymphomas?

Hodgkin lymphoma, non-Hodgkin lymphoma

3
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Characteristics of Hodgkin Lymphoma

1) more often localized to a single axial group of nodes

2) orderly spread by contiguity

3) mesenteric nodes and Waldeyer ring are rarely involved

4) extranodal presentation is rare

4
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Characteristics of non-Hodgkin lymphomas

1) more frequently involvement of multiple peripheral nodes

2) noncontiguous spread

3) Waldeyer ring and mesenteric nodes are commonly involved

4) extranodal presentation is common

5
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Classification of Hodgkin lymphomas:

Classic Hodgkin lymphoma and non classic Hodgkin lymphoma

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What cell is characteristic for Hodgkin lymphomas?

Reed-Sternberg cells

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What are the types of non Hodgkin lymphomas?

Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL)

8
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In what age are non Hodgkin lymphomas presented?

Patients older than 50 years (median 60 yoa)

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What is Richter syndrome

Transformation of CLL to diffuse large B-cell lymphoma

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What is the most common chromosomal translocation associated with follicular lymphoma?

chromosomal translocation involving BCL2

11
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What are the risk factors for developing MALT?

1) chronic infections (Helicobacter Pylori)

2) autoimmune disease (Sjögren syndrome, Hashimoto thyroditis)

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Localization of MALT:

stomach, salivary gland, thyroid (remains localized at the site of origin for a long time, spreading systemically only late in its course)

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What can MALT transform into?

Diffuse large B-cell lymphoma

14
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Translocation of which genes may lead to diffuse large B-cell lymphoma?

BCL6, BCL2, MYC

15
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Amplification of which gene in DLBCL has the worst outcome?

MYC amplification

16
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Mycosis fungoides are derived from what cells?

T cells (T-cell lymphoma)

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What is the most common variant of mycosis fungoides?

Sezary syndrome

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Define sezary syndrome

1) generalized erythrodermia

2) generalized lymphadenopathy

3) presence of neoplastic T cells in the skin, lymph nodes and peripheral blood