Midazolam (Versed) Overview

This set of flashcards covers key concepts and details regarding Midazolam, including its classification, mechanism of action, indications, contraindications, dosing, side effects, and precautions.

Midazolam

A benzodiazepine used for procedural sedation and as an anticonvulsant.

Mechanism of Action

Binds to GABA type A receptors in the brain, enhancing GABA's effects.

Indications for Midazolam

Procedural sedation, intubation sedation, post-intubation sedation, anticonvulsant therapy, handling combative patients, and treating musculoskeletal injuries.

Contraindications for Midazolam

Hypersensitivity, narrow-angle glaucoma, shock, alcoholic coma, myasthenia gravis, acute pulmonary insufficiency, COPD, pregnancy, and renal failure.

Adult Dose for Seizures

5 mg IN.

Adult Dose for Sedation

0.05 mg/kg (max 5 mg per dose), average 1 - 5 mg, titrate to effect.

Adult Dose for Combative/Violent Patient

2.5 mg IV or 5 mg IM (max 10 mg).

Pediatric Dose of Midazolam

0.05 - 0.2 mg/kg IV/IM/IN, titrate to effect; max 2.5 mg IV, max 5 mg IM/IN.

Side Effects of Midazolam

Respiratory depression, drowsiness, amnesia, altered mental status, bradycardia, tachycardia, PVCs, laryngospasm, bronchospasm, dyspnea.

Precautions When Using Midazolam

Risk of respiratory depression; emergency equipment must be available; caution in elderly patients.