Receptor Mediated Endocytosis

step 1

ligands bind to receptors in cell membrane

step 2

areas coated with ligands form deep pockets in membrane surface

step 3

pockets pinch off to form endosomes known as coated vesicles

step 4

coated vesicles fuse with primary lysosomes to form secondary lysosomes

step 5

ligands are removed and absorbed into cytoplasm

step 6

the lysosomal and endosomal membranes seperate

step 7

the endosome fuses with the cell membrane, and the receptors are again available for ligand binding