Module 5 Bacteriology: Helicobacter pylori & Campylobacter jejuni
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23 Terms
Helicobacter pylori
A Gram-negative curved rod
Transmission: H. pylori
person to person (usually by the fecal-oral route)
Helicobacter pylori
Microaerophile
Campylobacter jejuni
"Sea gull wing" shape
Campylobacter jejuni
A small motile, Gram-negative rod that appears as
curved, comma-, or S-shaped organisms
Transmission: C. jejuni
Consumption of contaminated food or drink, especially poultry products
Transmission: C. jejuni
Contact with infected animals or animal products
Gastroenteritis
Characterized by abdominal cramps, diarrhea
(bloody), HA, malaise, and fever.
Guillain-Barré syndrome
A form of ascending paralytic disease.
Campylobacter jejuni
Grows better at 42°C than 37°C
Antigenic structures and toxins
o LPS with endotoxic activity
o Cytopathic extracellular toxins
o Enterotoxins
H. pylori does not appear to invade the gastric mucosa,
but rather release various toxins such as:
o Mucinase
o Phospholipase
o Neutrophil-activating protein A
o Heat shock protein 60
o Cytotoxin-associated gene A protein (CagA)
o Vacuolating cytotoxin A (VacA)
H. pylori infection is a known independent risk factor
for the development of:
o Atrophic gastritis
o Gastric ulcer disease
o Gastric adenocarcinomas
o Gastric mucosa associated lymphoid tissue
(MALT) lymphomas
Gastric biopsy material + urea medium w/
indicator =
resulting pH changes the color of medium
Treatment: H. pylori (Triple therapy – 7 – 14 days)
o Proton-pump inhibitor (PPI; standard dose,
twice daily)
o Clarithromycin (500 mg twice daily)
o Amoxicillin (1 g twice daily)
Treatment: H. pylori (Quadruple therapy – 10 – 14 days)
o PPI
o Metronidazole (250 mg four times daily)
o Tetracycline (500 mg, four times daily)
o Bismuth
Campylobacter jejuni
A small motile, Gram-negative rod that appears as
curved, comma-, or S-shaped organisms
Selective media
Campy blood agar, Skirrow's media
Helicobacter pylori
Catalase and oxidase-positive; urease-positive
Helicobacter pylori
Motile (single and/or multiple monopolar flagella)