1: Drug Classes

Epinephrine / Adrenaline

Nonselective alpha + beta adrenoceptor agonist; catecholamine

Levonordefrin

Direct sympathomimetic vasoconstrictor; mostly alpha agonist

Norepinephrine / Noradrenaline

Alpha-1/alpha-2 and beta-1 agonist catecholamine

Dopamine

Dose-dependent dopamine, beta, and alpha receptor agonist

Oxymetazoline

Direct alpha agonist; topical sympathomimetic

Phenylephrine

Selective alpha-1 agonist

Methoxamine

Selective alpha-1 agonist

Mephentermine

Alpha-1 sympathomimetic vasopressor

Clonidine

Selective alpha-2 agonist; central sympatholytic

Dexmedetomidine

Highly selective alpha-2 agonist

Isoproterenol

Nonselective beta agonist

Dobutamine

Selective beta-1 agonist

Salbutamol / Albuterol

Selective beta-2 agonist

Terbutaline

Selective beta-2 agonist

Orciprenaline / Metaproterenol

Beta agonist with beta-2 activity

Salmeterol

Long-acting beta-2 agonist (LABA)

Formoterol

Long-acting beta-2 agonist (LABA)

Ephedrine

Indirect/direct sympathomimetic

Pseudoephedrine

Indirect sympathomimetic decongestant

Amphetamine

Indirect sympathomimetic stimulant

Methamphetamine

Indirect sympathomimetic stimulant

Methylphenidate

Indirect sympathomimetic; norepinephrine/dopamine reuptake inhibitor

Lisdexamfetamine

Prodrug amphetamine stimulant

Phenmetrazine

Sympathomimetic appetite suppressant (older agent)

Phentermine

Sympathomimetic appetite suppressant

Cocaine

Local anaesthetic; norepinephrine reuptake blocker; sympathomimetic

Imipramine

Tricyclic antidepressant (TCA); NE/5-HT reuptake blocker

Amitriptyline

TCA; NE/5-HT reuptake blocker

Desipramine

TCA; NE reuptake blocker

Nortriptyline

TCA; NE/5-HT reuptake blocker

Doxepin

TCA

Protriptyline

TCA

Venlafaxine

SNRI

Desvenlafaxine

SNRI

Duloxetine

SNRI

Levomilnacipran

SNRI

Isocarboxazid

MAOI

Phenelzine

MAOI

Tranylcypromine

MAOI

Pargyline

MAOI (historical antihypertensive)

Selegiline

Selective MAO-B inhibitor at usual doses

Entacapone

COMT inhibitor

Phenoxybenzamine

Nonselective alpha antagonist; irreversible

Phentolamine

Nonselective alpha antagonist; reversible

Prazosin

Selective alpha-1 antagonist

Terazosin

Selective alpha-1 antagonist

Doxazosin

Selective alpha-1 antagonist

Tamsulosin

Selective alpha-1 antagonist with higher prostate subtype affinity

Yohimbine

Selective alpha-2 antagonist

Tolazoline

Alpha-2 antagonist/vasodilator (mostly veterinary/historical)

Butoxamine

Selective beta-2 antagonist (research only)

Propranolol

Nonselective beta antagonist

Timolol

Nonselective beta antagonist

Nadolol

Nonselective beta antagonist

Oxprenolol

Nonselective beta antagonist with partial agonist activity

Pindolol

Nonselective beta antagonist with partial agonist activity

Sotalol

Nonselective beta blocker + class III antiarrhythmic

Metoprolol

Selective beta-1 antagonist

Atenolol

Selective beta-1 antagonist

Acebutolol

Selective beta-1 antagonist with partial agonist activity

Bisoprolol

Selective beta-1 antagonist

Esmolol

Ultra-short-acting selective beta-1 antagonist; IV

Labetalol

Mixed alpha and beta antagonist

Carvedilol

Mixed beta + alpha-1 antagonist

Bretylium

Adrenergic neuron blocker; antiarrhythmic

Guanethidine

Adrenergic neuron blocker

Reserpine

Catecholamine depleter

Methyldopa / Alpha-methyl dopa

False neurotransmitter; central alpha-2 agonist effect

Acetylcholine

Endogenous cholinergic agonist

Pilocarpine

Direct muscarinic agonist

Carbachol / Carbamylcholine

Direct cholinergic agonist

Methacholine

Direct muscarinic agonist

Bethanechol

Direct muscarinic agonist

Physostigmine

Reversible cholinesterase inhibitor; tertiary amine

Neostigmine

Reversible cholinesterase inhibitor; quaternary amine

Edrophonium

Short-acting reversible cholinesterase inhibitor

Pyridostigmine

Reversible cholinesterase inhibitor

Donepezil

Reversible acetylcholinesterase inhibitor

Rivastigmine

Cholinesterase inhibitor

Atropine

Muscarinic antagonist; belladonna alkaloid

Glycopyrrolate

Muscarinic antagonist; quaternary anticholinergic

Propantheline

Muscarinic antagonist; oral antisialagogue

Homatropine

Muscarinic antagonist

Scopolamine / Hyoscine

Muscarinic antagonist; belladonna alkaloid

Benztropine

Muscarinic antagonist; antiparkinson adjunct

Trihexyphenidyl

Muscarinic antagonist; antiparkinson adjunct

Ipratropium

Inhaled muscarinic antagonist

Tiotropium

Long-acting inhaled muscarinic antagonist (LAMA)

Oxybutynin

Muscarinic antagonist

Dicyclomine

Muscarinic antagonist/antispasmodic

Hexamethonium

Nicotinic ganglionic blocker (N-N); historical

Trimethaphan

Nicotinic ganglionic blocker (N-N)

Rocuronium

Nondepolarizing neuromuscular blocker; nicotinic N-M antagonist

Succinylcholine

Depolarizing neuromuscular blocker

Procaine

Ester local anaesthetic

Tetracaine

Ester local anaesthetic

Nitrous oxide

Inhalational gas general anaesthetic; weak anaesthetic; analgesic/sedative at lower doses

Isoflurane

Volatile inhalational anaesthetic vapor

Desflurane

Volatile inhalational anaesthetic vapor

Sevoflurane

Volatile inhalational anaesthetic vapor