Exam Study Guide 2: Week 8

Andogens: Meds

Testosterone cypionate; Testosterone gel

Androgens: MOA

Agonist to androgen receptors

Androgens: Tx

hypogonadism, HRT, endometriosis

Androgens: X

Breast/prostate Ca; Increased PSA, hct>50, gynecomastia, OSA, pregnancy

Androgens: SE

edema, increased HF, protstatic hyperplasia/Ca, OSA, decreased clotting, increased RBC, gynecomastia, decreased libido, ED

Androgens: DDI

Anticoagulants

Antiandrogens: MOA

Prevent effect of androgens on receptors

Antiandrogens: Tx

Prostate ca, BPH, hair loss, hiuritism

Antiandrogens: Meds

Finasteride; Leuprolide, Flutamide

Antiandrogens: Finasteride is a

5A reductase inhibitor

Antiandrogens: Finasteride: Tx

BPH, balding

Antiandrogens: Finasteride: SE

ED, decreased libido, gynecomastia

Antiandrogens: Leuprolide is a

Gonadotropin Releasing Inhibitor

Antiandrogens: Leuprolide: MOA

Inhibits leutinizing hormone; chemical castration is irreversible

Antiandrogens: Leuprolide: tx

Breast and prostate Ca; fibroids, endometriosis, precosious puberty

Antiandrogens: Flutamide is a

Direct Androgen

Antiandrogens: Flutamide: MOA

Direct androgen inhibitor

Antiandrogens: Flutamide: Tx

Prostate Ca w/radiation

Antiandrogens: Flutamide: Black Box

Hepatic failure, encephalopathy, death

Antiandrogens: Flutamide: DDI

Increased INR w/warfarin

Estrogens: meds

Estradiol (Estrace); Conjugated estrogen (Premarin)

Estrogens: MOA

Endogenous to female reproductive system. Made in ovary and adrenal cortex

Estrogens: Use

HRT; post menopausal/oopherectomy; contraception; prevent/txof osteoporosis

Estrogens: X

Estrogen dependent breast Ca; undiagnosed uterine bleeding; DVT arterial clot within 1 year; pregnancy

Estrogens: SE

Increased risk of breast/endometrial cancer; thromboletic events w/smoking; increased mi/htn risk, CV disease, stroke, LDL, HA, fluid retnetion

Estrogens: DDI

Benzos decrease efficacy

Estrogens: Monitor

Annual mammograms; pelvic exams

Estrogens: Edu

Take at same time daily

Estrogens: Black Box

thromboembolism, endometrial cancer

Antiestrogens: meds

Tamoxifen; Raloxifene

Antiestrogens: MOA

Selective estrogen receptor modulator; Increased FSH and LH + estrogen, stimulate ovaries

Antiestrogens: Tamoxifen: tx

Breast Ca in estrogen + tumors

Antiestrogens: Tamoxifen: SE

hot flashes, muscle cramps, increased T4

Antiestrogens: Raloxifene: Tx

Prevents osteoporosis

Antiestrogens: Raloxifene: SE

hot flashes, muscle cramps

Progesterone: Meds

Progesterone oral capsules; Medroxyprogesterone; Norethindrone

Progesterone: Progesterone oral capsules: Education

Take at same time everyday

Progesterone: Medroxyrogesterone: side effect

increased osteoporosis

Progesterone: MOA

Thickens endometrium for pregnancy; thickens cervical mucus and thins vaginal mucous; relaxes muscles in the fallopian tubes, In pregnancy: increases placenta development; delays lactation

Progesterone: tx

HRT menopause; prevent endometrial cancer; endometriosis +hiuritism

Progesterone: X

Pregnancy, thromboembolic disease; breast Ca, depression

Progesterone: SE

Increased white count; depression, irregular bleeding

Aromataste Inhibitors: Meds

Anastrozole, Letrozole, Exemestane

Aromataste Inhibitors: MOA

Reduce ciruclating estrogen

Aromatase Inhbitors: Use

Post op breast ca; estrogen positive breast Ca; advanced metastatic cancer drug of choice

Aromataste Inhbitors: SE

Pain syndromes; Loss of bone mass (take Vit D + Calcium); Leukopenia, Increased blood clots, Vertigo, Insomnia