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Andogens: Meds
Testosterone cypionate; Testosterone gel
Androgens: MOA
Agonist to androgen receptors
Androgens: Tx
hypogonadism, HRT, endometriosis
Androgens: X
Breast/prostate Ca; Increased PSA, hct>50, gynecomastia, OSA, pregnancy
Androgens: SE
edema, increased HF, protstatic hyperplasia/Ca, OSA, decreased clotting, increased RBC, gynecomastia, decreased libido, ED
Androgens: DDI
Anticoagulants
Antiandrogens: MOA
Prevent effect of androgens on receptors
Antiandrogens: Tx
Prostate ca, BPH, hair loss, hiuritism
Antiandrogens: Meds
Finasteride; Leuprolide, Flutamide
Antiandrogens: Finasteride is a
5A reductase inhibitor
Antiandrogens: Finasteride: Tx
BPH, balding
Antiandrogens: Finasteride: SE
ED, decreased libido, gynecomastia
Antiandrogens: Leuprolide is a
Gonadotropin Releasing Inhibitor
Antiandrogens: Leuprolide: MOA
Inhibits leutinizing hormone; chemical castration is irreversible
Antiandrogens: Leuprolide: tx
Breast and prostate Ca; fibroids, endometriosis, precosious puberty
Antiandrogens: Flutamide is a
Direct Androgen
Antiandrogens: Flutamide: MOA
Direct androgen inhibitor
Antiandrogens: Flutamide: Tx
Prostate Ca w/radiation
Antiandrogens: Flutamide: Black Box
Hepatic failure, encephalopathy, death
Antiandrogens: Flutamide: DDI
Increased INR w/warfarin
Estrogens: meds
Estradiol (Estrace); Conjugated estrogen (Premarin)
Estrogens: MOA
Endogenous to female reproductive system. Made in ovary and adrenal cortex
Estrogens: Use
HRT; post menopausal/oopherectomy; contraception; prevent/txof osteoporosis
Estrogens: X
Estrogen dependent breast Ca; undiagnosed uterine bleeding; DVT arterial clot within 1 year; pregnancy
Estrogens: SE
Increased risk of breast/endometrial cancer; thromboletic events w/smoking; increased mi/htn risk, CV disease, stroke, LDL, HA, fluid retnetion
Estrogens: DDI
Benzos decrease efficacy
Estrogens: Monitor
Annual mammograms; pelvic exams
Estrogens: Edu
Take at same time daily
Estrogens: Black Box
thromboembolism, endometrial cancer
Antiestrogens: meds
Tamoxifen; Raloxifene
Antiestrogens: MOA
Selective estrogen receptor modulator; Increased FSH and LH + estrogen, stimulate ovaries
Antiestrogens: Tamoxifen: tx
Breast Ca in estrogen + tumors
Antiestrogens: Tamoxifen: SE
hot flashes, muscle cramps, increased T4
Antiestrogens: Raloxifene: Tx
Prevents osteoporosis
Antiestrogens: Raloxifene: SE
hot flashes, muscle cramps
Progesterone: Meds
Progesterone oral capsules; Medroxyprogesterone; Norethindrone
Progesterone: Progesterone oral capsules: Education
Take at same time everyday
Progesterone: Medroxyrogesterone: side effect
increased osteoporosis
Progesterone: MOA
Thickens endometrium for pregnancy; thickens cervical mucus and thins vaginal mucous; relaxes muscles in the fallopian tubes, In pregnancy: increases placenta development; delays lactation
Progesterone: tx
HRT menopause; prevent endometrial cancer; endometriosis +hiuritism
Progesterone: X
Pregnancy, thromboembolic disease; breast Ca, depression
Progesterone: SE
Increased white count; depression, irregular bleeding
Aromataste Inhibitors: Meds
Anastrozole, Letrozole, Exemestane
Aromataste Inhibitors: MOA
Reduce ciruclating estrogen
Aromatase Inhbitors: Use
Post op breast ca; estrogen positive breast Ca; advanced metastatic cancer drug of choice
Aromataste Inhbitors: SE
Pain syndromes; Loss of bone mass (take Vit D + Calcium); Leukopenia, Increased blood clots, Vertigo, Insomnia