Section 5: Telomeres and Replication Termination AND Section 6: Mutations and Replication Control

Part 5

Telomeres consist of:
A) Random sequences
B) rRNA genes
C) Short tandem repeats (TTAGGG in humans)
D) Centromeric DNA

C

The enzyme that extends the 3’ end of chromosomes is:
A) Ligase
B) Gyrase
C) Primase
D) Telomerase

D

Telomerase is best described as a:
A) Protein-only enzyme
B) DNA-only helicase
C) Ribonucleoprotein reverse transcriptase
D) RNA polymerase

C

The RNA component of telomerase is called:
A) TERT
B) TERC
C) CAF
D) ARS

B

The protein component of telomerase responsible for catalysis is:
A) TERT
B) TERC
C) DnaA
D) Pol α

A

The shelterin complex stabilizes:
A) t-loops at chromosome ends
B) Okazaki fragments
C) ARS sequences
D) RNA primers

A

Loss of telomerase activity in human cells is associated with:
A) Immortality of cancer cells
B) Cellular aging and senescence
C) Faster replication rates
D) Enhanced DNA repair

B

In cancer cells, telomerase activity is typically:
A) Absent
B) Reduced
C) Retained or upregulated
D) Repressed

C

Temperature-sensitive mutations are useful because they:
A) Are always lethal
B) Only express a mutant phenotype under restrictive conditions
C) Occur only in eukaryotes
D) Affect RNA synthesis

B

A ligase-deficient mutant cell would have difficulty:
A) Initiating replication
B) Joining Okazaki fragments
C) Proofreading mismatches
D) Synthesizing primers

B